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A. Bharath kumar1*, S.P. Zakiullah1, B. Kumar1, Sk. Kareemulla1, Ramesh Dhani2 1Department of Pharmacy Practice, Annamcharya college of Pharmacy, Rajampet, A.P, India-518218 2Department of Pharmaceutical Chemistry, Ratnam Institute of Pharmacy, Nellore, A.P, India-524346. A B S T R A C T It is a group of metabolic diseases in which there is high blood sugar levels over a prolonged period. ... Read More »
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Category Archives: Pharmaceutical Chemistry and New drug design
Development and Validation of RP-HPLC Method for the Estimation of Sitagliptin Phosphate in Bulk and Its Tablet Dosage Form
I. Arulraj1, P. Vembu2 and A. Chenthilnathan1* 1Department of Pharmaceutical Chemistry, Manonmaniam Sundaranar University, Tirunelveli – 627 012, Tamil Nadu, India. 2Bafna Pharmaceuticals Limited, Grantlyon village, Chennai – 600 052, Tamil Nadu, India. A B S T R A C T A simple and sensitive reversed-phase liquid chromatographic method has been developed and validated for the estimation of Sitagliptin phosphate ... Read More »
Synthesis and Evaluation of Some Substituted New Pyrazoline Derivatives of Biological Interest
Amol S Dighe* Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, Loni, Maharashtra, India. A B S T R A C T The synthesis, structure and biological activity of Pyrazoline derivatives have long been the focus of research interests in the field of Medicinal Chemistry. A number of Pyrazoline derivatives have been reported to possess interesting biological activities ... Read More »
Development and Validation of a Stability Indicating RP-HPLC Method for the Determination of Piroxicam in Pharmaceutical Dosage Form
A. Chandra Prabha1, M. Sankar2 and A. Chenthilnathan1* 1Department of Pharmaceutical Chemistry, Manonmaniam Sundaranar University, Tirunelveli–627012, Tamil Nadu, India. 2Caplin Point Laboratories Ltd., Gummidipoondi, Chennai–601201, Tamil Nadu, India A B S T R A C T A stability-indicating RP-HPLC was developed and validated for the determination of Piroxicam in bulk and its injection dosage form. The separation was carried out ... Read More »
Preventive Effect of Premna Latifolia against High Fructose Diet Induced Insulin Resistance, Hyperlipidemia and Obesity in Male Wister Rats
Gampa Vijaya Kumar*1, K. Ramprasad2 1Professor and Head, Dept. of Pharmacy, KGR Institute of Technology and Management, Rampally, Keesara,Rangareddy, Telangana, India. 2Department of Pharmacology, Sree Chaitanya Institute of Pharmaceutical Sciences, L.M.D Colony, Thimmapur, Karimnagar, Telangana, India. A B S T R A C T The aim of this study was to investigate ant diabetic effect of premna latifolia on the ... Read More »
Spectrophotometric Determination of Moxifloxacin Hydrochloride using Palladium (Pd-II) ions in micellar medium
Madhuri.D1*, Chandrasekhar K.B2, Devanna N3, Somasekhar G4 1Department of Pharmaceutical Analysis, Dr. K.V. Subba Reddy Institute of Pharmacy, Kurnool, A. P, India 2Director & Professor, OTPRI-JNTUA, Anantapur, A.P, India-515002 3Professor, Department of Chemistry, JNT University, Anantapur A.P, India-515002 4Department of Pharmaceutical Chemistry, Safa College of Pharmacy. Kurnool, A.P, India A B S T R A C T A simple ,sensitive ... Read More »
Analytical Method Development and Validation for the Estimation of Efavirenz by RP-HPLC Method in Bulk and Pharmaceutical Dosage Form
Gobala Krishnan P*1, Munisekhar V, Ranjit Singh B. Rathore Department of Pharmaceutical Chemistry, Vagdevi college of Pharmacy & Research centre, Nellore, Andhra Pradesh, India. A B S T R A C T The chromatographic conditions were successfully developed for the separation of Efavirenz by using KromosilColumn (100-5 C18.60×4.6mm), flow rate was 1ml/min, mobile phase ratio was Acetonitril: Phosphate buffer PH ... Read More »
Novel 4-Thiazolidinone derivatives act as potential Voltage Sensitive Sodium Channel Inhibitors
Soma Acharjee1, Asish Bhaumik*2, V. Shwetha3, Sk. Nagulmeera2, N. Santhosh Kumar2, M. Swapna2 1Department of Pharmaceutical Chemistry, Regional Institute of Pharmaceutical Science and Technology, Agartala, Tripura, India-799005. 2Department of Pharmaceutical Chemistry, Teja College of Pharmacy, Kodad, Nalgonda-508206, Telangana, India. 3Department of Pharmaceutical Analysis, Pratishta Institute of Pharmaceutical Sciences, Durajpally, Chivemla, Nalgonda-508214, Telangana State, India. A B S T R A C T The ... Read More »
Genotoxic Impurity Profiling of Imatinib Mesylate
1M. Rajavardhan Reddy*, 2Dr. R. Suresh, 3Dr.K. Kannan 1Research Scholar, Annamalai University, Tamil Nadu, India 2Department of Pharmaceutical Chemistry, Annamalai University, Tamil Nadu, India 3Head of the Department, Pharmaceutical Sciences, Annamalai University, Tamil Nadu, India A B S T R A C T Genotoxic impurities (GTIs) in pharmaceuticals are of increasing concerns to both pharmaceutical industries and regulatory agencies due ... Read More »
Analytical Method Development and Validation for the Simultaneous Estimation of Sertraline hydrochloride and Alprazolam by RP-HPLC Method in Bulk and Pharmaceutical Dosage Form
Gobala Krishnan P*, Munisekhar V, Ranjit singh B Rathore Department of Pharmaceutical Chemistry, Vagdevi college of Pharmacy and Research centre, Nellore, A. P, India. A B S T R A C T The chromatographic conditions were successfully developed for the separation of Sertraline hydrochloride and Alprazolam by using C18 Column (150mm x 4.6mm) 5 µm, flow rate was 1 ml/min, ... Read More »
