Tuesday , 16 April 2024

Preparation and Characterization of the Poly Herbal Gel for the Treatment of Psoriasis Disease

Sravanthi Yamsani1*, Parameshwar Aleti2, Sravanthi.P3, Ramyakrishna Samala4, Manjula Katkuri5
S.R.R. College of Pharmaceutical Sciences, Valbhapur (v), Elkathurthy (m), Hanumakonda (D), Telangana

A. J. Med. Pharm, Sci., 2024, 12(1): 09-15
DOI: https://doi.org/10.30904/j.ijctpr.2024.4615

A B S T R A C T
The main objective of present study is to prepare and evaluate polyherbal gel for treatment of psoriasis by using the collection of plant extracts and by using the chemicals like carbopol 940 and 934, xanthangum. For quick relief in different allergic conditions and skin irritations. The main objective of present study is to prepare and evaluate a polyherbal gel of curcumin, banana, orange, neem, aloe for Psoriasis for quick relief in different pain, acne, rashes, and burning sensation. The Calibration curve of Polyherbal gel in phosphate buffer pH 6.8-7 in were plotted. Gelling agent used in poly herbal gels carbopol 940, carbopol 934 and xanthan gum. All the prepared gells were evaluated from surface pH (6.2-7.0), spreadability (4-5.8) antimicrobial activity (2-2.2cm) were studied. All the gels prepared were formed to be smooth non sticky, homogenous & transparent with no visible reticulate matter. The surface PH was found to be in the range of 6.8-7 which is close to the neutral pH which indicated that the gel may have less potential to irritate. For the Identification of spreadability of gel formulation the spreadability apparatus which contain two glass slides of (20x20cm) is used. All the formulation of gels was stored in container and they are visually observed to identify for their appearance of any type of aggregates in the gel formulations. The drug content present in the formulation was identified with the help of linear regression analysis of calibration curve. Among six formulations, the F3 formulation was released more drug content when compared to other formulations. The content of active constituent was estimated spectrophometrically by using 268 nm λmax of herbal gel.

Keywords: antimicrobial activity, curcumin, banana, orange, neem, aloe

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