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Mohan Vikas P1*, Chandu Babu Rao2
*1Research Scholar Acharya Nagarjuna University, Guntur
2Pridarshini Institute of Pharmaceutical Sciences, Guntur
DOI: https://doi.org/10.30904/j.ijmpr.2019.4645
Int. J. Med. Pharm. Res., 2019, 7(6): 237-243
A B S T R A C T
Nocturnal asthma is a variable exacerbation of the underlying asthma condition associated with increases in symptoms, need for medication, airway responsiveness, and/or worsening of lung function. Theophylline medications exhibit a shorter T max and a greater C max when they are ingested in the evening (at time night) than morning. Indeed the bioavailability of theophylline preparation was found to show a threefold increase when dosed in the evening (at time night) as opposed to the morning. Administration time differences in drug kinetics occur in both children and adults. The exact mechanisms of the administration time dependent differences in theophylline kinetics are unknown. In accordance with the chronomodulated therapy of asthma, the lag time criterion of 5 hours was satisfied by tablet plug containing 16% of HPMC K100LV(Batch C5). The in-vivo lag time was 4h. In-vitro lag time of 5.1 h could be due to less shear under in-vitro conditions, as compared to shear of peristalsis in the intestine.
Keywords: Theophylline, Chronomodulated, Asthma, Bioavailability
