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Category Archives: Pharmaceutical Chemistry and New drug design

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A Prospective Study on Assessment of Antimicrobials Prescribing Pattern in Various Departments of Tertiary Care Hospital

Amara Swathi1*, B. Kumar2 1PG Research Scholar, Department of Pharmacy Practice, Ratnam Institute of Pharmacy, Nellore, A.P. 2Professor, Department of Pharmacy Practice, Ratnam Institute of Pharmacy, Nellore, A.P. A B S T R A C T Microorganisms include bacteria, viruses, protozoan’s, and fungi such as mold and mildew.1 You may find antimicrobial products in your home, workplace, or school. The ... Read More »

Analytical Method Development and Validation for the Simultaneous Estimation of Decitabine and Cedazuridine by RP-HPLC Method

Dr. Gampa Vijay Kumar*1, B. Sravanthi2, N. Swetha3 1Professor and Head, Dept. of Pharmacy, KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India. 2KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India. 3KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India. A B S T R A C T High performance liquid chromatography is ... Read More »

Design and development of Ethosomal Gel of Diacerein by using cold method

B. Madhura, M. Kishore Babu* Department of Pharmaceutics, Krishna Teja Pharmacy College, Tirupati-517506, Chittoor Dist, Andhra Pradesh A B S T R A C T Trans dermal route offers several potential advantages over conventional routes. These advantages includes avoidance of first pass metabolism, predictable and extended duration of action, minimizing undesirable side effects, utility of short half-life drugs, improving physiological ... Read More »

Analytical Method Development and Vaidation for Ombitasvir and Paritaprevir in Combined Dosage Form by RP-HPLC

K.Nithiyananthan1*, K.V.S.Prasadarao2 1Research Scholar,  Acharya Nagarjuna University, Guntur, Andhra Pradesh 522510. 2Principal, Rahul Institute  of Pharmaceutical Sciences And Research, Chirala, Andhra Pradesh 523157 A B S T R A C T Ombitasvir and Paritaprevir by using Thermosil C18 column (4.0×125mm) 5µ, flow rate was 1ml/min, mobile phase ratio was (70:30 v/v) methanol: Sodium acetate buffer pH 3 (pH was adjusted ... Read More »

Investigation of Cardiac Protective Activity of Methanolic Extracts of Garcinia Indica in Rats

Saini Supraja1, Dr. Nagaraju, M.Kulkarni2, Dr. Vijaya Kumar Gampa3* 1KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India. 2Asso. Professor, KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India. 3Professor and Head, Dept. of Pharmacy, KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India. A B S T R A C T Atherosclerotic heart ... Read More »

Evaluation of Phytochemical screening and in vitro Anti-inflammatory activity of Ethanolic extract of Jatrophagossypifolia Linn.

P. Sailaja* Department of Pharmacology, Ratnam Institute of Pharmacy, Pidathapolur, Muthukur, SPSR Nellore -524 346 A B S T R A C T The present study was aimed to evaluate the phytochemical screening and in-vitro anti- inflammatory activity of ethanolic extract of Jatrophagossypifolia Linn. It reveals the presence of considerable amount of alkaloid, steroid, phenolic substances and vitamin C (Ascorbic ... Read More »

Development of Enhanced Site Specific Periodontal Drug Delivery Systems for Minocycline HCl and Ciprofloxacin Gels

Mukamalla Suresh1*, Rohit Saraswat School of Pharmacy, OPJS University, Churu, Rajasthan A B S T R A C T Ciprofloxacin hydrochloride, fluoroquinone antibiotic and Minocycline hydrochloride, tetracycline antibiotic that could be used in the treatment of periodontitis for localized therapy. The ciprofloxacin gel was formulated using biodegradable PVP, CMC (5%, 10%, 20%, 30% w/w) and poloxamer. The gel was evaluated ... Read More »

Development and Characterization of Gastro Retentive In Situ Gel of ziprasidone Hydrochloride

Uma Rani Gandi1*, R. Nagaraju2 1R.B.V.R.R. Women’s College of Pharmacy, Barkatpura, Hyderabad, Telangana 2Sri Padmavathi Mahila university, Tirupathi. A B S T R A C T The present study aimed at development of Ziprasidone HCl (anti-psychotic agent) into a prolonged release oral dosage form to reduce the frequency of administration which is very difficult for psychic patients. Ziprasidone has poor ... Read More »

Simultaneous determination of Mo(VI) and W(VI) using Second order derivative spectrophotometry

Dr.Srinivas Jagarlapudi*1, Dr.V. Suryanarayana Rao2, A. Ravi Kumar3, Panchumarthi. Srinivas4, CH. Sunil Babu5 Obvez Labs Pvt. Ltd.  Plot No. 22 & 23, ALEAP Industrial Area, Pragathi Nagar, Hyderabad, Telangana-500090, India. A B S T R A C T A simple, selective and sensitive spectrophotometric method has been developed for the simultaneous determination of Molybdenum (VI) and tungsten (VI) using 3,4-dihydroxybenzaldehyde ... Read More »

Evaluation of Hepatoprotective Activity of Berberis Vulgaris on Azathioprine Induced Oxidative Stress in Rats

Gampa Vijaya Kumar1, Dr. Y. Sridhar2, M.Anitha3 1Professor and Head, Department of Pharmacy, KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India. 2Professor, KGR Institute of Technology and Management, Kesara, Rangareddy, Telangana, India. 3KGR Institute of Technology and Management, Kesara, Rangareddy, Telangana, India. Abstract Hepatotoxicity may be predictable or unpredictable. Predictable reactions typically are dose related and occur ... Read More »

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