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M. Penchala Anitha*1, P. Venu Gopalaiah2, Y. Prapurnachandra3, M. Penchala Pravallika1
1Student, Department of Pharmaceutics, Ratnam Institute of Pharmacy, Pidthapolur (Village), Muthukur (Mandal), Nellore, Andhra Pradesh – 524343, India.
2Professor, Head of the Department, Vice – Principal, Department of Pharmaceutics, Ratnam Institute of Pharmacy, Pidthapolur (Village), Muthukur (Mandal), Nellore (Dist), Andhra Pradesh– 524343, India.
3Professor, Principal, Department of Pharmacology, Ratnam Institute of Pharmacy, Pidthapolur (Village), Muthukur (Mandal), Nellore (Dist), Andhra Pradesh–524343, India.
A. J. Med. Pharm, Sci., 2024, 12(1): 01-04
DOI: https://doi.org/10.30904/j.ijctpr.2024.4572
A B S T R A C T
One of the most promising oral medication delivery systems is the gastro-retentive system because of its ability to remain in the stomach area for extended periods of time. This makes the medication more soluble, which enhances bioavailability and lowers drug waste. The foundation of microballoons drug delivery systems is a non-effervescent system made up of spherically shaped, empty particles without a core, ideally less than 200 micrometers. The floating microballoons demonstrated a possible method for stomach retention by demonstrating gastroretentive controlled release delivery with an effective way to increase bioavailability. In environments with a higher pH, they dissolve less readily. Delivery devices using microballoons prolong drug retention in the stomach pH and improve the solubility of medications that are less soluble in high pH environments. The preparation, temperature, and smoothness of the surface affect the creation of a cavity inside the microballoons, which in turn affects their floatability and release rate.
Keywords: Microballoons, Gastroretentive, Drug delivery system, Emulsion solvent diffusion method.
