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About author B. Mohammed Ishaq*, Dr. Hindustan Abdul Ahad, Shaik Muneer, Praveena B Department of Pharmaceutical Analysis, Balaji College of Pharmacy, Anantapur, A.P India E-mail: [email protected] Abstract Simple, rapid and sensitive spectrophotometric procedure was developed for the analysis of atomoxetine hydrochloride (ATH) in pure form as well as in pharmaceutical formulations. The method was based on the reaction of ATH ... Read More »
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Category Archives: Chemical Sciences and Chemical research
Spectrophotometric Simultaneous Estimation of Valsartan and Hydrochlorothiazide in Pharmaceutical Dosage Form using Mixed Hydrotropic Solubilisation Approach
About author Jyoti Vilas Jadhav*, Kishorkumar Burade Govt. College of Pharmacy, Vidyanagar Karad, Satara, Maharashtra- 415124, India Email: [email protected] Abstract Two validated UV spectrophotometric methods for the simultaneous estimation of Valsartan and Hydrochlorothiazide in pure powder and in two component tablet dosage form have been developed, utilising simultaneous equation and absorbance ratio method. The ... Read More »
A Quantitative Structure-Activity Relationship Study of Caffeic Acid Amides as Selective Inhibitors of Matrix Metalloproteinase
About author Prithvi Singh* Department of Chemistry, S.K. Government Post-Graduate College, Sikar-332 001, India E-mail: [email protected] Abstract A quantitative structure-activity relationship (QSAR) study is carried out on caffeic acid amides as the inhibitors of matrix metalloproteinase (MMP). The inhibition action, for the sub-type MMP-9, is quantitatively analyzed following the non-parametric (Fujita-Ban) and parametric approaches. The Fujita-Ban analysis has identified the substituents ... Read More »
Biological Evaluation of Some Newly Synthsized Thiazolidinone Derivatives for their Analgesic Activity
About author Pravesh Gangwar*, Dr.Pankaj Sharma, Dr. Birendra Shrivastava. Jaya Sharma, Shikha Sharma Derartment of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India. E-mail: [email protected] Abstract Two new thiazolidinone derivatives were prepared by brominating 1-acetylnaphthalene in chloroform followed by condensation with substituted benzaldehyde thiosemicarbazones using ethanol to get 4-naphthalen-1-yl-2-{2-[(substituted phenyl)methylidene]hydrazino}-1,3-thiazoles. These thiazole derivatives were then cyclized to title compounds by ... Read More »
Synthesis and Characterization of New Thiazolidinone Derivatives and Screening for Their Anti-Inflamatory Activity
About author Pravesh Gangwar*, Dr.Pankaj Sharma, Dr. Birendra Shrivastava.Jaya Sharma, Shikha Sharma Department of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India. E-mail: [email protected] Abstract In the present study, a thiozolidinones derivatives were synthesized by the 1-actynaphthalene. 1-actynaphthalene on brominating with chloroform gives 1-bromoactynaphthalene which was reacted with substituted benzaldehyde thiosemicarbazone in ethanol as a solvent give 4-naphthalen-1-yl-2-{2-[(substituted phenyl) methylidene] ... Read More »
Redox Reactions of Cobalt (III) Complexes of A-Hydroxy acids by Pyridinium Dichromate in Surfactants
About author B. Mohammed Nawaz* PG and Research Department of Chemistry, Islamiah College, Vaniyambadi-635752,Tamil Nadu, India E.mail: [email protected] Abstract The kinetics of one electron transfer mode seems to be unavailable for PDC with Cobalt (III) bound and unbound complexes of α-hydroxyacids in surfactant medium, PDC oxidizes Cobalt(III) bound and unbound α-hydroxyacids. It rules out the synchronous C-C bond fission and ... Read More »
Method development and validation by RP-HPLC for the estimation of Zolmitriptan in bulk and its dosage form
About author D. Samson Israel*, D.Gowri Sankar, K.Krishna Chaitanya, K.Balaram Kumar, K.Vinod University college of Pharmaceutical sciences, Andhra University, Visakhapatnam, A.P E-mail: [email protected] Abstract Zolmitriptan is used in the acute treatment of migraine attacks. It was quantified by reverse phase HPLC equipped with Sunniest (C18, 150 x 4.6 mm, 5.0 µ) column and mobile phase using pH 8.5 buffer and methanol as organic modifiers ... Read More »
A Review on Magic Bullets
About author R.B. Desi Reddy, S. Lakshmi Sindhuri*, N. Pratibha Department of Pharmaceutical Analysis and Quality Assurance, Nalanda Institute of Pharmaceutical Sciences, Kantepudi, Sattenapalli, A.P, India E-mail: [email protected] Abstract Magic bullets are the agents that cures or remedies by attacking a specific disease without causing harmful side effects. German medical scientist Paul Ehrlich (1854–1915) used the expression “magic bullet” to describe ... Read More »
Synthesis, Characterization and Antioxidant studies of 2-Benzylthio benzimidazole derivatives
About author Sumayya K K*, Kamalabhai Amma V K, Babu G, Biju C R Department of Pharmaceutical Chemistry, Devaki Amma Memorial College of Pharmacy, Pulliparamba, Chelembra, Malappuram, India-673 634. *E mail: [email protected] Abstract The present study was undertaken to evaluate the antioxidant activity of some Mannich bases of 2-benzylthio benzimidazole derivatives. Mannich bases of 2-benzylthio benzimidazole were synthesized by formaldehyde, 2-benzylthio ... Read More »
Marine Organism: A Rich Source of Bioactive Metabolites
About author Nisha Choudhary*, Sunil Singh, Jyoti Rai, Inamullah, Surabhi Sharma Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University Bareilly (U.P) E-mail: [email protected] Abstract Natural products have proved to be a rich source of therapeutic agents. Plant extracts have been used for thousands of years in the treatment of human diseases. It is somewhat contradictory to note that most of ... Read More »
