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Author Details Muraleedharan Nair. M.K*, Ajitha. P.S, Rejimon. P.K Postgraduate & Research Department of Chemistry, Maharaja’s College, Ernakulam – 682011, Kerala, India E-mail : [email protected] ABSTRACT Nitrogen–Oxygen donor ligands, 2,3-dimethyl-4-(iminopyridoxyl)-1-phenyl-3-pyrazoline-5-one (L1), 5-(hydroxymethyl)-4-{(1-Z)-[2-N(2-hydroxylphenyl]ethanimidoyl)-2-methyl}pyridine-3-ol-hydrochloride(L2), 5-(hydroxymethyl)-4-{(1-Z)-[2-N(3-hydroxyl-phenyl]ethanimidoyl)-2-methyl}pyridine-3-ol-hydrochloride (L3) have been synthesized. New lanthanide(III) complexes of the three ligands [La(L1)2(NO3)3] (a), [La(L1)2Cl2]Cl (b), [La(L1)2ClO4](ClO4)2 (c), [La(L2)2(NO3)2]NO3 (d), [La(L2)2Cl3] (e), [La(L2)2(ClO4)](ClO4)2 (f), [La(L3)2(NO3)2]NO3 (g), [La(L3)2)Cl3] (h) and ... Read More »
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Category Archives: Chemical Sciences and Chemical research
Synthesis and characterization of lanthanide(III) nitrate complexes derived from two isomeric Schiff base ligands and comparative study of their antimicrobial activity
ABOUT AUTHOR Muraleedharan Nair. M.K*, Ajitha. P.S, Rejimon. P.K. Postgraduate & Research Department of Chemistry, Maharaja’s College, Ernakulam–682011, Kerala, India Email: [email protected] ABSTRACT The ligands and complexes were characterized by elemental analysis, molar conductivity, CHN analysis, magnetic susceptibility measurements, and spectroscopic studies such as IR, UV, and NMR. The in-vitro biological effects of lanthanide nitrate complexes of two isomeric Schiff ... Read More »
Evaluation of Proximate Screening of Phyllanthus Amarus
ABOUT AUTHOR Shirish S. Pingale*, Shrikant S. Shewale, Dilip B Satpute Department of Chemistry, Gramonnati Mandal’s, Arts Com. and Science College Narayangaon, Pune Abasaheb Garware College, Pune (Affiliated to University of Pune) E-mail: [email protected] ABSTRACT Natural products have traditionally provided many of the drugs in use. Despite the achievement of synthetic chemistry and advances towards rational drug design, natural products ... Read More »
CHARACTERIZATION OF THE INTERACTION BETWEEN TWO ANTI-VIRAL DRUGS AND EGG ALBUMIN
ABOUT AUTHOR S.Bakkialakshmi*,V.Barani Department of Physics, Annamalai University, Annamalai Nagar, India. E-mail: [email protected] Abstract The binding of two anti-viral drugs quercetin and Amantadine to Egg albumin was investigated by fluorescence spectroscopy under simulation of physiological conditions. The quenching mechanism was suggested according to the fluorescence measurement. The Stern-volmer quenching constants were determined. In addition, binding constants were also calculated at ... Read More »
Chemometric descriptor based QSAR rationales for the MMP-13 inhibition activity of non-zinc-chelating compounds
ABOUT AUTHOR Brij Kishore Sharma*, Prithvi Singh Department of Chemistry Government Post-Graduate College, Bundi-323 001, India Shri Kalyan Government Post-Graduate College, Sikar-332 001, India *E-mail: [email protected] ABSTRACT The MMP-13 inhibition activity of non-zinc-chelating compounds has been quantitatively analyzed in terms of chemometric descriptors. The statistically validated quantitative structure-activity relationship (QSAR) models provided rationales to explain the inhibition ... Read More »
FPLC- A PROTEIN LOVING CHROMATOGRAPHIC TECHNIQUE (A MODIFICATION OF HPLC)
About author : Jony Mallik*, Abdullah Al Faruq Department of Pharmacy, Southern University Bangladesh, Chittagong, Bangladesh *e-mail: [email protected] INTRODUCTION Protein is the collection of amino-acid moieties and essential part of human nutrition. Amino acids play central roles both as building blocks of proteins and as intermediates in metabolism. The 20 amino acids that are found within proteins convey a vast ... Read More »
X-ray Crystallography adds a new dimension to analytical world (Based on X-ray diffraction)
About author : Jony Mallik*, Sourav Das Department of Pharmacy, Southern University Bangladesh, Chittagong, Bangladesh *e-mail: [email protected] INTRODUCTION : X-ray is a very potential EMR (Electromagnetic Radiation) having a very short wave length ranges from 10-6 ~10-8 cm. It can travel with the velocity of light and can also be reflected, refracted, polarized and absorbed. Due to its variation in ... Read More »
METHOD DEVELOPMENT AND ITS VALIDATION FOR QUANTITATIVE SIMULTANEOUS DETERMINATION OF DEXAMETHASONE AND GATIFLOXACIN IN OPHTHALMIC SOLUTION BY RP-HPLC
About author : Ankit Agarwal*, Subhash Dadhich, Sunil Kumar Tiwari, Kashyap Nagariya R & D Division, Ahlcon Parenterals (I) Ltd., Bhiwadi, Rajasthan, India *e-mail: [email protected] ABSTRACT : To develop a simple, rapid and accurate HPLC method for simultaneous quantitative determination of Dexamethasone and Gatifloxacin in ophthalmic solution. Chromatographic separation was achieved with PDA detector using Inertsil C18, 250 x 4.6mm, ... Read More »
Mass Spectrometry – A vulnerable analytical tool for molecular formula & mass determination
About author : Jony Mallik* Department of Pharmacy, Southern University Bangladesh, Chittagong-4200. *e-mail: [email protected] INTRODUCTION Pharmaceutical analysis has greatest importance in pharmaceutical science, specially in terms of Research & Development (R&D), Drug-Product design, Quality Control Department of a Pharmaceutical Industry. Among the number of spectroscopic analytical techniques, Mass Spectrometry occupied a large area of whole analytical zone. The very important ... Read More »
A COMPARISION OF ANALYTICAL METHOD VALIDATION PROCEDURES
About author: Chinmaya Keshari Sahoo* Research Scholar,Dept. of Pharmaceutics, OUCT, Osmania University,A.P, India *e-mail: [email protected] INTRODUCTION : Analytical method validation is a regulatory requirement that refers to the evaluation and proving that the selected analytical method shall ensure reproducible and reliable results adequate for the intended purpose.The process of analytical method validation should demonstrate that the method is fit for ... Read More »
