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Katikala Dharmendra*, Dr. C. Sreedhar, T. Sreenivasa Rao, Rikshaya Tamang, Meghnath Chaudhary, Mohamed adam Department of Pharmaceutical Analysis, Karnataka College of Pharmacy, #33/2,Thirumenahalli,Hegde Nagar main road, Bangalore – 560064, KA. India. A B S T R A C T Pirfenidone, 5-methyl-1-phenyl-2-(1H)-pyridine is a novel Anti-fibrotic agent approved for mild to moderate Idiopathic pulmonary fibrosis (IPF). Isocratic reverse phase high performance ... Read More »
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Category Archives: Chemical Sciences and Chemical research
Pharmacological Evaluation of Antidepressant Activity of Piper Betel Leaves and Clove
Shaik Salmasultana*, P. Sukumari, SK. Shafi, D. Maheswari, P. Ramsai, K. Sasikumar, A. Sravani Department of Pharmacology, Jagan’s Collegeofpharmacy, Gangalakandriga, Nellore A B S T R A C T The antidepressant activity of eugenol excluded clove extract was investigated using two different models of stress induced depression (forced swim test and Tail suspension method). Animals were divided into different groups each ... Read More »
Method Development and Validation of Sofosbuvir and Ledipasvir in API & Its Pharmaceutical dosage forms by RP-HPLC
Shinnde Sandeep* Department of Pharmaceutical Analysis & Quality Assurance ,SSJ College of Pharmacy,Vattinagulapally, Gandipet, Hyderabad – 500075, Telangana State A B S T R A C T Ledipasvir is indicated in patients with hepatitis C virus (HCV) genotype 1 for treatment of chronic hepatitis as a combination therapy, which includes peg interferonalfa and ribavirin. Ledipasvir is a protease inhibitor for ... Read More »
Synthesis and antimicrobial activity of Schiff base of quinolene-2-ones
Dr. Alka Pradhan and Sanjay Kumar Vishwakarma* Professor, Department of Chemistry, S. N. Govt. G.P.G. College Bhopal. *Research Scholar, Department of Chemistry, S .N. Govt. G.P.G. College Bhopal. A B S T R A C T In the present study, we synthesized Schiff bases of quinolene-2-one and their antibacterial activity was evaluated by wells diffusion method. Schiff bases of quinolene-2-one ... Read More »
Development and Validation of new UV-Visible Spectrophotometric Method for the Estimation of Losartan in Tablet Dosage Form
*Suruchi Samparna Acharya, R. Maneesha, L. Manikanta, M. Ajay Kumar, P. Gowthami, B. Hareesh Jagan’s College of Pharmacy, Jangala Kandriga (V), Muthukuru (M), Nellore, Andhra Pradesh, India. A B S T R A C T A simple, Accurate, precise method was developed for the estimation of Losartan in Tablet dosage form. Solutions of Losartan were prepared in solvent like methanol ... Read More »
Simultaneous Estimation of Amlodipine and Atenolol by Using Reverse Phase High Performance Liquid Chromatography in Bulk and Marketed Formulation
Devanapelly Shashikantha Rao* Lecturer, Department of Chemistry, C.K.M. Arts and Science College, Warangal- 506006, Andhra Pradesh, India. Abstract A simple precise and accurate reverse phase high performance liquid chromatography (RP-HPLC) method has been developed for the simultaneous estimation of Amlodipine and Atenolol. Chromatographic separation was achieved on Altima C18 column (4.6×150mm, 5µ) using the mobile phase consisting of Methanol: TEA ... Read More »
Development of Validated Stability Indicating Assay Method by RP-HPLC for Simultaneous Estimation of Azilsartan Medoximil and Chlorthalidone in Their Bulk and Combination Form
S. Priyanka Yadav*1, P. Sowjanya2, Dr. Gampa Vijaya Kumar3 1,2KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India, 3Professor and Head, Dept. of Pharmacy, KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India A B S T R A C T Method was established for simultaneous estimation of Azilsartan medoxomil and Chlorthalidone by RP-HPLC method. The ... Read More »
Development and Validation of Stability Indicating RP-HPLC Method for the Simultaneous Estimation of Torsemide and Spiranolactone in Bulk Drug and Pharmaceutical Dosage Form
V. Haribaskar, Ramesh Dhani, B. Swathi* Department of Pharmaceutical Analysis, Ratnam Institute of Pharmacy, Pidathapolur, Nellore, A.P, India A B S T R A C T Simple precise and accurate method was developed for the estimation of Torsemide and Spiranolactone. The mobile phase consisting 20% Buffer: 80%ACN. The column was used: Inertsil ODS 4.6*210mm, 5µ with flow rate 1ml/min using ... Read More »
Analytical Method Development and Validation of Tenofovir Distroxil Fumarate (TDF) in Bulk and Formulations by using Folin-Ciocalteau Reagent through UV-Visible Spectroscopy
R. Nageswara Rao*, Dr. D. Madhuri, U. Ramadevi, P. Poojitha, P. Sarala, S. Raj Kumar, T. Bhagyalakshmi, Y. Harshavardhan Yadav Department of Pharmaceutical Analysis and Quality Assurance, Creative Educational Society’s College of Pharmacy, Kurnool, Andhra Pradesh A B S T R A C T A simple, economical, rapid, accurate, precise spectrophotometric method has been developed and validated according to ICH Q2 ... Read More »
Method Development, Validation and Stability Studies of Nutipotant and Palanosetran in Pharmaceutical Dosage Form by RP-HPLC
Baddam Anusha, P. Sirisha* Joginapally B.R. Pharmacy College, Yenkapally, Moinabad, Hyderabad, Telangana–500075. ABSTRACT A new method was established for simultaneous estimation of Nutipatant and Palonosetran by RP-HPLC method. The chromatographic conditions were successfully developed for the separation of Olmesertan medoxomil and Chlorthalidone by using YMC 4.6*150mm 5µ, flow rate was 1.0ml/min, mobile phase ratio was 70% buffer and 30% methanol, ... Read More »
