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Rameeja Pattan*, V. Haribaskar, Pasala Sandhya Mounika, Ramesh Dhani, B. Prathap Department of Pharmaceutical Analysis, Ratnam Institute of Pharmacy, Pidathapolur, Muthukur, Nellore A B S T R A C T A simple, fast, accurate, precise, reproducible Stability indicating Reverse phase High performance liquid chromatography (RP-HPLC) method was developed and validated for the determination of Lumacaftor and Ivacaftor in Bulk and ... Read More »
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Category Archives: Chemical Sciences and Chemical research
Method Development and Validation of Acetazolamide Single Drug Molecule by Using UV Double Beam Spectrophotometer
Rameeja Pattan*, M. Charitha, M. Hemalatha, C. Lalitha, P. Pravallika, M. Vyshnavi, V. Sneha Priya Ratnam Institute of Pharmacy, Pidathapolur, Muthukur, SPSR Nellore-524 346, Andhra Pradesh A B S T R A C T This UV-spectrophotometric technique is quite simple, accurate, precise, reproducible, and sensitive. The UV method has been developed for quantification of Acetazolamide in tablet formulation. The validation ... Read More »
Male Antifertility Activity of Hydro-Alcoholic Stem and Leaf Extracts of Ecballium Elaterium on Male Wistar Rats
1Sarath Chandiran Irisappan, 2Jaya Kumar Annamalai* 1Professor, Sun Institute of Pharmaceutical Education and Research, Nellore, A.P, India-524346 2Research Scholar, PRIST University, Thanjavur, Tamilnadu, India- 613403 A B S T R A C T Objective: The objective was to investigate the male antifertility effect of hydro-alcoholic stem and leaf extracts of Ecballium elaterium on male Wistar rats. Methods: The animals were divided ... Read More »
Green Chemistry for Environmental Sustainability: The waste reduction approach
Deepak M. Nagrik*, Damodar M. Ambhore£ *Department of Chemistry, G.S.College, Khamgaon, Distt. Buldana, M.S., India-444303 £Department of Chemistry, Shri Pundlik Maharaj Mahavidyalaya, Nandura, Dist. Buldana, M.S., India-443404 A B S T R A C T “Green Chemistry” is the universally accepted term to describe the movement towards more environmentally acceptable chemical processes and products. It encompasses education, research, and commercial ... Read More »
Synthesis of N-(3-Oxo-2,4-dihydro-1H-quinoxalin-2-yl)benzamide
El Houssine Mabrouk1 1Laboratory of Organic Chemistry, Faculty of Sciences DharElMehraz, University Sidi Mohamed Ben Abdellah, Fez, B.P.:1796-Fès Atlas, Morocco ABSTRACT The title compound, N-(3-Oxo-2,4-dihydro-1H-quinoxalin-2-yl)benzamide2, was synthesized in high yield, via N-alkylation reaction of methyl 2-azido-2-benzamidoacetate or methyl 2-bromo-2-benzamidoacetate with o-phenylenediaminein acetone, with the presence of diisopropylethylamine(DIEPA) as a base. The structure of the prepared compound was characterized by 1H, ... Read More »
Synthesis of methyl 2-benzamido-2-(5-(4-methoxyphenyl)tetrazol-1-yl)acetate and methyl 2-benzamido-2-(5-(4-methoxyphenyl)tetrazol-2-yl)acetate
El Houssine Mabrouk Laboratory of Organic Chemistry, Faculty of Sciences Dhar El Mehraz, University Sidi Mohamed Ben Abdellah, B.P. 1796, Fez, Morocco ABSTRACT Heterocyclic amino acids represent a well-known group of organic compounds also presenting biological activity. We developed an environmentally benign, efficient, and simple method for the Synthesis of new racemic α-tetrazolyl α-carboxylic aminoesters derivatives by nucleophilic substitution of ... Read More »
Spectroscopic Analysis by UV &FT-IR of Cassia obtusifolia Seed Ethanolic Extract and Phytochemical Screening
Shahin Aziza, Shahal Ahmedb, MD.Zahangir Alamb aSenior Scientific Officer, Chemical Research Division, BCSIR Laboratories, Dhaka-1000, Bangladesh Council of Scientific and Industrial Research, Dhaka, Bangladesh. bDepartment of Applied Chemistry and Chemical Engineering, Islamic University, Kushtia-7003, Bangladesh ABSTRACT Cassia obtusifolia is an important medicinal plant medicinal plant. The present work deals with phytochemical screening, UV and FT-IR spectroscopy of ethanolic extract of Cassia ... Read More »
A Novel RP-HPLC Method Development and Validation for the Estimation of Pyrimethamine in Bulk and its Pharmaceutical Formulation
U. Srinivasulu*1, N. Devanna2, A. Sandhya 3, B. Siva Sai Kiran3, S. Muneer3 1Associate Professor of Chemistry, SBSYM Degree College, Kurnool-518004, A.P., India 2Professor and Director, Department of Chemistry, JNTUA-Oil Technological and Pharmaceutical Research Institute, Ananthapuramu-515002, A.P., India. 3Department of Pharmaceutical Sciences, JNTUA-Oil Technological and Pharmaceutical Research Institute, Ananthapuramu-515002, A.P., India A B S T R A C T A simple, ... Read More »
Simultaneous Estimation of Moxonidine and Hydrochlorothiazide in Tablets by RP-HPLC
A. Thenmozhi, H. Mubeena*, N. Venkateshan Department of Pharmaceutical Analysis, Arulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnankoil -626 190, Tamil Nadu. A B S T R A C T A simple, precise, specific sensitive and accurate reverse phase high performance liquid chromatographic (HPLC) method was developed for the determination of Moxonidine and Hydrochlorothiazide in tablet dosage form. The separation ... Read More »
Analytical Method Development and Validation for the Determination of Griseofulvin in bulk and Its Solid Oral Dosage form using RP-HPLC
U. Srinivasulu*1, N. Devanna2, M.Suneetha3, B. Siva Sai Kiran3, S. Muneer3 1Associate Professor of Chemistry, SBSYM Degree College, Kurnool-518004, A.P., India 2Professor and Director, Department of Chemistry, JNTUA-Oil Technological and Pharmaceutical Research Institute, Ananthapuramu-515002, A.P., India. 3Department of Pharmaceutical Sciences, JNTUA-Oil Technological and Pharmaceutical Research Institute, Ananthapuramu-515002, A.P., India A B S T R A C T A simple, sensitive ... Read More »
