Saturday , 8 May 2021

Synthesis and antimicrobial activity of Schiff base of quinolene-2-ones

Dr. Alka Pradhan and Sanjay Kumar Vishwakarma*
Professor, Department of Chemistry, S. N. Govt. G.P.G. College Bhopal.

*Research Scholar, Department of Chemistry, S .N. Govt. G.P.G. College Bhopal.

A B S T R A C T
In the present study, we synthesized Schiff bases of quinolene-2-one and their antibacterial activity was evaluated by wells diffusion method. Schiff bases of quinolene-2-one (1 to 3 named as Q2af-Q2ah) were prepared by refluxing with substituted aromatic aldehydes. The final test compounds has purified and characterized by IR, 1HNMR and Mass Spectral studies. M.P. of these compounds was confirmed by open capillary method instrument chemline Cl 725.  They have evaluated for antibacterial activity. Compounds were active against Klebsiella pneumonia and Enterococcus faecalis. While ciprofloxacin was used as standards.

Keywords: quinolene-2-one, Schiff base

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