Saturday , 8 May 2021

Development and Validation of new UV-Visible Spectrophotometric Method for the Estimation of Losartan in Tablet Dosage Form

*Suruchi Samparna Acharya, R. Maneesha, L. Manikanta, M. Ajay Kumar, P. Gowthami, B. Hareesh
Jagan’s College of Pharmacy, Jangala Kandriga (V), Muthukuru (M), Nellore, Andhra Pradesh, India.

A B S T R A C T
A simple, Accurate, precise method was developed for the estimation of Losartan in Tablet dosage form. Solutions of Losartan were prepared in solvent like methanol and UV spectrum of each were recorded by scanning between 200-400 nm. Losartan was found to be linear in a concentration range of 5-25µg/ml. The absorbances of these solutions were noted at wavelength 208 respectively. Calibration curves were plotted using concentration Vs absorbance at wavelength of 208 nm and the slope, intercept and correlation coefficient values were found to be 0.999 respectively. The assay of Losartan was performed with tablets and the % assay was found to be 100.16 which shows that the method is useful for routine analysis. The acceptance criteria of precision is RSD should be not more than 2.0% and the method show precision 0.16.  The acceptance criteria of intermediate precision is RSD should be not more than 2.0% and the method show precision 0.09. 

Keywords: Losartan, UV-Spectrophotometry

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