Friday , 12 July 2024

In Vitro Studies on Anti-Cataract Activity of Phoenix dactylifera L., Seed

Shaik Khathija*, E. Rajani, C. Madhavi Latha, Y. Prapurna Chandra
Department of Pharmacology, Ratnam Institute of Pharmacy, Pidathapolur (V&P), Muthukur (M), SPSR Nellore-524 346

A b s t r a c t
Cataract can be considered a paradigmatic protein conformation or amyloid disease because aggregation and precipitation of proteins from the normally clear soluble lens result in opacification and cataract. Cataract is painless clouding appearance on the internal lens of our eye. It blocks the light entering on lens of eye. This mostly happens to the older people, also those affected with metabolic disorder. Nowadays a children and young people are also affected because of the digital lifestyle. Early childhood cataract is a big challenge to overcome the visual eye. Opacity of the lens causes some chemical changes in the cellular and membrane constituents. The toxic effects of reactive oxygen species (ROS) or free radicals are neutralized in the lens by both enzymatic and non-enzymatic antioxidants. Several studies suggest the use of medicinal plants having antioxidant potential is beneficial against cataract. The most of the scientist selected the selenite induced cataract for oxidative damage induced cataract .we taken the naphthalene induced cataract model estimating the antioxidant level and compared with different groups of rats. β sitosterol is the active phytoconstitutes in the Phoenix dactylifera L., possess the antioxidant activity may be responsible for the anticataract activity.

Keywords: cataract, reactive oxygen species, Phoenix dactylifera

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