Purini Sai Charitha*, P. Sailaja, C. Madhavi Latha, Y. Prapurna Chandra
Department of Pharmacology, Ratnam Institute of Pharmacy, Pidathapolur (V&P), Muthukur (M), SPSR Nellore District – 524 346
A B S T R A C T
Peptic ulcer and other acidic symptom affect up to ten percentages of the humans with sufficient severity to prompt victims to seek medical attention. The more significant disease condition requiring medical focus is ulcer and gastro esophageal disease. In our study Desmostachya bipinnata plant extracts its phytochemical investigation will be a useful tool for the identification and authentication of the plant for industrial and further research purpose, which will be related to the antioxidant activity. Antioxidants, which can scavenge free radicals, have an important role in pharmacological systems. Antioxidants are emerging as prophylactic and therapeutic agents. Hence, antioxidant was also evaluated for the potent extract. And now I have under taken the study of evaluation anti-oxidant and antiulcer activity of Desmostachya bipinnata plant extracts by using in-vitro methods. The results analyzed from the present study have indicate that AEDB possesses antioxidant and antiulcer effect on aspirin induced ulcers. The preliminary phytochemical screening of whole plant extracts indicate in presence of flavonoid, alkaloid, proteins, amino acids and terpenoids, fixed oil and glycosides The antioxidant screening shows that it showed reducing power to DPPH radicals. But the efficiency showed that far below from Vitamin C. The concentration of the AEDB needed to scavenge 50% superoxide anion (IC50) equal to that of standard hence the plant extract have the significant antioxidant activity The antiulcer effect is screened in ethanol extract of Desmostachya bipinnata on NSAID induced anti-ulcer study. The results get from these study have been shown that ethanol extract of Desmostachya bipinnata produce antiulcer effect. In aspirin induced model, there is reduction in ulcer index, total acidity, total volume of gastric contents, total protein concentration and higher concentration of glutathione content and pH of gastric secretion they compared with control group.
Keywords: Desmostachya bipinnata, DPPH, Anti-oxidant