Wednesday , 19 June 2024

Evaluation of In-Vitro Anti Urolithiatic Activity of Justicia Tranquebariensis

Maanam Anjali*, Y. Prapurna Chandra, C. Madhavi Latha
Department of Pharmacology, Ratnam Institute of Pharmacy, Pidathapolur (V&P), Muthukur (M), SPSR Nellore District – 524 346

Abstract
The present investigation is to study about the preliminary phytochemical analysis of Justicia tranquebariensis indicated the presence of Flavonoids, quinones, glycosides, coumarins and steroids. In-vitro Calcium oxalate crystallization inhibition study was evaluated. From this study conclude that the ethanol, ethyl acetate, and hexane extracts of Justicia tranquebariensis. inhibits the calcium oxalate crystallization in the order of 58%, 46% and 39% respectively. In-vitro turbidity method was evaluated that these extracts inhibits the calcium oxalate nucleation in the order of 73%, 62% and 61% respectively. Among the various extracts, the ethanolic extract produces more potent anti urolithiatic activity.  The study provides basic evidence that the justicia tranquebariensis has the beneficial effect for the treatment of urolithiasis. Further studies are required to elucidate the molecular mechanism of action and its therapeutic potential in the treatment of urolithiasis.

Keywords: Justicia tranquebariensis, calcium oxalate crystallization, turbidity method, urolithiasis

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