Friday , 19 July 2024

Effect of Packaging and Storage Conditions on the Quality of Some Commercially Available Amoxicillin Oral Suspension in Benin City, Nigeria

Ibukun Olanrewaju ADELEKE*, Felix Ebitimi OMONI
Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Igbinedion University Okada, Nigeria

A b s t r a c t
The clinical control of diseases frequently receives oral amoxicillin powder for reconstitution into suspension. Some of these suspensions are stored in bottles while some in plastic containers. There has been report of product instability which may be due to problem of reconstitution, storage condition or container used for storage. The aim of this work was to investigate possible instability of the suspension in plastic versus glass container, during the period of storage from the first to fourteenth day using standard methods.Parameters such as organoleptic properties, pH, sedimentation volume, rheological assessment as well as particle size and shapeswere evaluated. Six brands of amoxicillin oral suspension were obtained from three local community pharmacies in Benin City, Nigeria. Three of them were packaged in bottle containers while the other three in plastic containers. The various brands were coded 1,2,3,4,5 and 6. They were then stored in the refrigerator during the period of study. From the study, it was found that those stored in plastic containers gave better results compared to those in glass containers. A significant caking was observed in three of the brands, namely 1,3 and 5. From the research work, it can be concluded that it is better to pack amoxicillin oral suspension in the plastic bottle.

Keywords: Amoxicillin oral suspension, plastic container, glass container, six brands

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