Saturday , 13 July 2024

Synthesis of methyl 2-benzamido-2-(5-(4-methoxyphenyl)tetrazol-1-yl)acetate  and methyl 2-benzamido-2-(5-(4-methoxyphenyl)tetrazol-2-yl)acetate

El Houssine Mabrouk
Laboratory of  Organic Chemistry, Faculty of  Sciences Dhar El  Mehraz, University  Sidi  Mohamed Ben  Abdellah,  B.P. 1796,  Fez,  Morocco

Heterocyclic amino acids represent a well-known group of organic compounds also presenting biological activity. We developed an environmentally benign, efficient, and simple method for the Synthesis of new racemic α-tetrazolyl α-carboxylic aminoesters derivatives by nucleophilic substitution of methyl α-azido glycinate N-benzoylated with p-methoxyphenyl-1H-tetrazole. The structure of the these compounds have been characterized from the rigorous analysis of their spectral 1H-NMR, 13C-NMR and MS.
Keywords: Tetrazole, Nucleophilic substitution, α-Aminoesters, Methyl α-azido glycinate

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