Murugan Mounika1, Nallapu Prathyusha Evangelin2, Nomula Chaitanya3, B. Prabhakar Reddy*4
1,2,3Vignan Institute of Pharmaceutical Sciences, Vignan Hills, Deshmukhi, Yadadri, Bhongir, Telangana, India.
4Associate Professor, Department of Pharmaceutics, Vignan Institute of Pharmaceutical Sciences, Vignan Hills, Deshmukhi, Yadadri, Bhongir, Telangana, India.
A B S T R A C T
In the present work, Aceclofenac microspheres using HPMC K 4 M., Eudragit L100, Eudragit RLPO as copolymers were formulated to deliver Aceclofenac via oral route. The results of this investigation indicate that ionic cross linking technique Ionotropic gelation method can be successfully employed to fabricate Aceclofenac microspheres. The technique provides characteristic advantage over conventional microsphere method, which involves an “all-aqueous” system, avoids residual solvents in microspheres. Other methods utilize larger volume of organic solvents, which are costly and hazardous because of the possible explosion, air pollution, toxicity and difficult to remove traces of organic solvent completely. Micromeritic studies revealed that the mean particle size of the prepared microspheres was in the size range of 512-826µm and are suitable for bioadhesive microspheres for oral administration. Increase in the polymer concentration led to increase in % Yield, % Drug entrapment efficiency, Particle size, % swelling and % Mucoadhesion.The in-vitro mucoadhesive study demonstrated that microspheres of Aceclofenac using sodium alginate along with Eudragit RLPO as copolymer adhered to the mucus to a greater extent than the microspheres of Aceclofenac using Sodium alginate along with HPMC K 4 M., Eudragit L100 as copolymers.
Keywords: Aceclofenac, Microspheres