Monday , 20 May 2019

Evaluation of Hepatoprotective Activity of Methanolic Leaf Extract of Evolvulus nummularius Linn.

G. Sindhu*, V. Jayashankar Reddy, T. Usha Kiran Reddy
S V U College of Pharmaceutical Sciences, S.V University, Tirupati–517502.

A B S T R A C T
The present study was aimed to explore the hepatoprotecive activity in aqueous whole plant extract of EN on rats. Acute toxicity studies were conducted in Male Wistar rats by using OECD guidelines No.423. The   protective   effects   shown   by   EN   with   biochemical   parameters (SGOT,SGPT & ALP) and histological parameters recorded  with CCl4  induced hepatotoxic rat models clearly depicts that EN possessed hepatoprotective activity. The 400 mg/kg and 200mg/kg of EN treated groups showed comparable hepatoprotective activity with standard drug sylimarin. The 400 mg/kg of methanolic extract of Evolvulus nummularius treated group has better action the 200 mg/kg body weight.

Keywords: Cobicistat Darunavir, RP-HPLC, Phosphate buffer, ACN

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