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Tag Archives: RP-HPLC

Analytical Method Development and Validation for the Simultaneous Estimation of Tezacaftor and Ivacaftor by RP-HPLC Method

Chitraju Prathyusha, P. Sabiya*, B. Poornima Department of Pharmaceutical Analysis, Krishna Teja Pharmacy College, Tirupathi, A.P, India. A B S T R A C T The aim of present research work made to develop and validate simultaneous estimation of Tezacaftor and Ivacaftor was done by RP-HPLC. The optimized mobile phase was consists of Acetonitrile: Phosphate buffer pH 2.5 mixed in ... Read More »

Development of new simultaneous RP-HPLC method for the estimation of Dapagliflozin and Saxagliptin in tablet dosage form

M. Kavitha*, C.S. Parameswari, B.V. Ramana, G. Nagarajan Dr.K.V.Subba Reddy Institute of Pharmacy, Kurnool, Andhra Pradesh, India A B S T R A C T The aim of present research work made to develop and validate RP-HPLC method for the simultaneous estimation of Dapagliflozin and Saxagliptin in bulk and combined dosage form. The optimized mobile phase was consists of 0.1% ... Read More »

Simultaneous estimation and validation of Lumacaftor and Ivacaftor in the tablet dosage form using RP-HPLC method

S. Kantha Lakshmi*, C.S. Parameswari, B.V. Ramana, G. Nagarajan Dr. K.V. Subba Reddy Institute of Pharmacy, Kurnool, Andhra Pradesh, India A B S T R A C T The aim present research work to development and validation of RP-HPLC method for the simultaneous estimation of Lumacaftor and Ivacaftor. Chromatographic separation was evaluated by Phenomenex C18 column (250 X 4.6 mm, ... Read More »

Development of New simultaneous RP-HPLC method for the estimation of Pentazocine HCl and Naloxone HCl in tablet dosage form

M. Sowbhagya Lakshmi*, C.S. Parameswari, B.V. Ramana, G. Nagarajan Dr. K.V. Subba Reddy Institute of Pharmacy, Kurnool, Andhra Pradesh, India A B S T R A C T The aim of present research work made to develop and validate RP-HPLC method for the simultaneous estimation of Pentazocaine and Naloxone in bulk and combined dosage form. The optimized mobile phase was ... Read More »

Development of new simultaneous RP-HPLC method for the estimation of Glecapravir and Pibrentasvir in tablet dosage form

M. Lakshmi Prasanna*, C.S. Parameswari, B.V. Ramana, G. Nagarajan Dr. K.V. Subba Reddy Institute of Pharmacy, Kurnool, Andhra Pradesh, India A B S T R A C T The aim present research work to development and validation of RP-HPLC method for the simultaneous estimation of Glecapravir and Piberentasvir. Chromatographic separation was evaluated by Xterra C18 column (250 X 4.6 mm, ... Read More »

A Novel Validated Stability Indacating Method for Simultaneous Estimation of Emtricitabine, Tenofovir and Efavirenz in Tablet Dosage Form by RP-HPLC

Kommana Balaram Kumar*, Yohanes Ayele, Birhanu Motbatnor aAssistant Professor, Department of Pharmaceutical analysis and Quality Assurance School of Pharmacy, Haramaya University, Ethiopia. bDepartment of clinical pharmacy, H.O.D, School of pharmacy, Haramaya University, Ethiopia cLecturer, Department of pharmaceutical analysis and quality assurance School of pharmacy, Haramaya University, Ethiopia A  B  S  T  R A C T The objective of the current study ... Read More »

Analytical Method Development and Validation for the Simultaneous Estimation of Ranitidine and Dicyclomine in Bulk and Pharmaceutical Dosage Form by RP-HPLC

K. Surendra*, V. Gunasekaran, K. Venkata Arun Teja Rao’s College of Pharmacy, Chemudugunta, Venkatachalam, Nellore, Andhra Pradesh-524320 A  B  S  T  R A C T A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Ranitidine and Dicyclomine, in its pure form as well as in tablet dosage form. Chromatography was carried ... Read More »

Antioxidant, Hepatoprotective Activity and RP-HPLC Analysis of Moringa Oleifera Pods Methanolic Extract against Alcohol Induced Hepatotoxicity

Konda Ravi Kumar, A. Prathyusha* Department of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur, Andhra Pradesh. A  B  S  T  R A C T In this study the pods of Moringa oleifera were extracted with methanol and subjected to analysis of the polyphonolic compounds by RP-HPLC method and to appraise the free radical scavenging activity and hepatoprotective activity aligned with the ... Read More »

RP-HPLC Method Development and Validation for the Simultaneous Estimation of Elbasvir and Grazoprevir Fixed dosage form

Purnacandra Rao Mendu* Department of Chemistry, Bundelkhand University, Jhansi, Uttar Pradesh, India A  B  S  T  R A C T The present research work focused on development and validation for the RP-HPLC method for the simultaneous estimation of Elbasvir and Grazoprevir in bulk and fixed dosage form. Chromatographic separation was achieved on by using Eclipse XDB -C18 (150×4.6mm, 5µm particle ... Read More »

Evaluation of Hepatoprotective Activity of Methanolic Leaf Extract of Evolvulus nummularius Linn.

G. Sindhu*, V. Jayashankar Reddy, T. Usha Kiran Reddy S V U College of Pharmaceutical Sciences, S.V University, Tirupati–517502. A B S T R A C T The present study was aimed to explore the hepatoprotecive activity in aqueous whole plant extract of EN on rats. Acute toxicity studies were conducted in Male Wistar rats by using OECD guidelines No.423. ... Read More »

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