Protective Effect of Terminalia Bellerica Chlorofom Extract for Its Anti-Ulcer Activity

T. Usha Kiran Reddy*, K. Pakeeriah, G. Sindhu, G. Vivek Sai, A. Kalyani, K. Anitha Raj, K. Thyagaraju
S V University College of Pharmaceutical Sciences, S V University, Tirupati

A B S T R A C T
Peptic ulcer is a most common disease of humans. A number of drugs including proton pump inhibitors and H2 receptor antagonists are available for the treatment of peptic ulcer, but clinical evaluation of these drugs has shown incidence of relapses, side effects like arrhythmias, impotence, gynaecomastia, arthralgia, hypergastrinemia and haemopoeitic changes and drug interactions. The aim of present study was protective effect of terminalia bellerica chloroform extract for it’s anti- ulcer activity. Under the research to perform the phytochemical study, acute toxicity studies and aspirin induced ulcer activity. Choloroformic extract of Terminalia belirica, showed the presence flavanoids and their glycosides tannins, triterpenoids, and saponins. These phytoconstituents present in the extract could be the possible agents involved in the prevention of gastric lesions induced by aspirin.
Keywords: Peptic ulcer, Anti-Ulcer, Aspirin, Chloroform, Treminalia Bellerica