Thursday , 30 June 2022

Posterior Eye Therapeutics

M. Jyoshna1*, Dr. P. Venkatesh2, N. Sumanth kumar3
1-3Jagans Institute of Pharmaceutical Sciences, Jangala Kandriga, Nellore

The treatment of eye diseases of the posterior segment of the eye, such as age-related macular degeneration, cytomegalovirus retinitis, diabetic retinopathy, posterior uveitis and retinitis pigmentosa, requires novel drug delivery systems that can improve the efficacious delivery of therapeutic drug concentrations. The development of new biodegradable and nonbiodegradable sustained-release systems for injection or transplantation into the vitreous as well as drug-loaded nanoparticles, microspheres and liposomes. The drug delivery systems utilize topical, systemic, subconjunctival, intravitreal, transscleral and iontophoretic routes of administration. The systemic application of drugs is another method of access to the posterior segment. The drugs are administered orally or intravenously, enabling distribution throughout the body via the blood-stream. From the blood, the drugs can easily enter the choroidal extravascular space as the choroid has an extensive vascular network and leaky walls. The development of new alternative administration routes to the posterior segment of the eye, including intravitreal and periocular pathways can helpful for reducing the eye diseases. 

Keywords: Eye diseases, drug delivery system, intravitreal and periocular pathways.

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