Thursday , 7 December 2023

Formulation Development and Evaluation of Lamivudine Sustained Release Tablets

Mekala Swetha*1, V. Leela Lakshmi2
1M. Pharmacy 2nd Year, Narayana Pharmacy College, Nellore, Andhra Pradesh, India-524003
2Department of Pharmaceutics, Narayana Pharmacy College, Nellore, Andhra Pradesh, India-524003

A b s t r a c t
Lamivudine is used widely in treatment of Hepatitis B and AIDS either alone or in combination with other antiviral drugs because of its water solubility and shorter half-life (5-7 hrs) drug requires frequent dosing by oral route, off various recent techniques for controlling drug release. The study was undertaken with an aim to formulation development and evaluation of Lamivudine sustained release tablets using polymers hydroxypropylmethylcellulose and ethylcellulose. Lactose monohydrate was used as channeling agent and or as filler.  Preformulation study was done initially and results directed for the further course of formulation.  Based on preformulation studies different formulations of Lamivudine were prepared using selected excipients. FT-IR study performed for the identification and compatibility study of drug with polymers and found the characteristics peaks of various groups and matched with pharmacopoeial standard. Powder and blends were evaluated for tests – bulk density, tapped density, compressibility index, Hausner’s ratio before being punched as tablets.  From the above results and discussion it is concluded that formulation of sustained release tablet of Lamivudine containing 80 mg of hydroxypropyl-methylcellulose E15 (high viscosity grade) and 80 mg of ethylcellulose i.e. formulation F7 can be taken as an ideal or optimized formulation of sustained release tablets for 16 hours release as it fulfills all the requirements for sustained release tablet and our study encourages for the further clinical trials and long term stability study on this formulation.

Keywords: Lamivudine, sustained release tablets, hydroxypropyl-methylcellulose E15, ethylcellulose.

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