Kamjula Matha Priya*1, Dr. S.Sujatha2
1M. Pharmacy 2nd Year, Department of Pharmaceutics, Narayana Pharmacy College, Nellore, Andhra Pradesh, India-524003
Department of Pharmaceutics, Narayana Pharmacy College, Nellore, Andhra Pradesh, India-524003
A b s t r a c t
Flutrimazole is a wide-spectrum antifungal drug. It is used for the topical treatment of superficial mycoses of the skin. Flutrimazole is an imidazole derivative. Present study was aimed to formulate and evaluate microspheres loaded transdermal gel containing Flutimazole as a model drug by employing Xanthan gum, Methocel K4M and Methocel K15M as polymers microspheres were prepared by using aqueous ionotropic gelation method. Different polymers, different drug to polymer(s) ratio(s) and other parameters were screened to study their effects on properties of microspheres and to optimize each parameter. The microspheres obtained were subjected to preformulation studies like bulk density, tapped density, angle of repose, carr’s index, hausner’s ratio the results obtained were with in the limit.The microspheres were characterized by Percentage yield, Drug entrapment efficiency, Particle size analysis, then the optimized microspheres formulation F8 were incorporated into the gel prepared with Methocel K100M, Sodium CMC and Guar gum as polymers and was evaluated by parameters like Visual inspection , pH measurement , Spreadability studies , Viscosity and in-vitro drug release by using franz diffusion cell for results from the diffusion results FG4 showed maximum percentage drug release of 96.85 hence it was considered as the optimized formulation.
Keywords: Flutrimazole, ionotropic gelation method, transdermal gel, Xanthan gum, Methocel K4M, Methocel K15M, Methocel K100M, Sodium CMC and Guar gum.