Athuppakam Narmada*1, Dr. S. Sujatha2
1M. Pharmacy 2ndYear, Narayana Pharmacy College, Nellore, Andhra Pradesh, India-524003
2Department of Pharmaceutics, Narayana Pharmacy College, Nellore, Andhra Pradesh, India-524003
A b s t r a c t
Pindolol is a nonselective beta blocker which is used in the treatment of hypertension. It is also an antagonist of the serotonin 5-HT1A receptor, preferentially blocking inhibitory 5-HT1A auto receptors, and has been researched as an add-on therapy to selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression. The aim of the present study was to develop buccal formulation of Pindolol to maintain constant therapeutic levels of the drug for over 12 hrs. HPMCK15M, Locust bean gum and Xanthan gum were employed as polymers. Pindolol dose was fixed as 10 mg. Total weight of the tablet was considered as 60 mg. Polymers were used in the concentration of 10 mg, 20 mg and 30 mg concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F4) showed better and desired drug release pattern i.e.,98.53 % in 12 hours. It followed zero order release kinetics mechanism.
Keywords: Pindolol, Buccal Tablets, HPMCK15M, Locust bean gum and Xanthan gum.