B. Venkateswara Reddy*, M. Suresh, K. Navaneetha
Department of Pharmaceutics, St. Pauls College of Pharmacy, Turkayamjal, Hayathnagar, R.R.Dist-501510, India
A B S T R A C T
Ezetimibe is an orally active anti-cholesterol agent, acts by inhibiting the absorption of cholesterol at the brush border of small intestine. The objective of the present study was to formulate and evaluate immediate release tablets of Ezetimibe. The immediate release formulations were formulated by using different diluents and disintegrants like lactose monohydrate, microcrystalline cellulose of two grades 101and 102, pregelatinized starch, croscarmellose sodium. All the formulations were developed by the wet granulation method employing povidone k30 in purified water as binding agent. All the formulations were evaluated for both official and unofficial tests the results are within the limits. All the formulations were investigated for in-vitro drug release studies in 0.45% SLS in 0.05M acetate buffer pH 4.5 of volume 500 ml in USP paddle type II apparatus for 60min. The results of dissolution studies indicated that the formulation F-7 containing croscarmellose sodium, microcrystalline cellulose (Avicel 101), and lactose monohydrate, having disintegration time 3 min 10 sec and showed maximum of 96.5% of drug release with in 60min, so it is considered as optimized formulation.
Keywords: Immediate release tablets, Ezetimibe, Wet granulation method, Disintegrants.