Thursday , 11 July 2024

Floating Drug Delivery Systems as Gastro retentive Drug Delivery Systems – A Review

C. Saravanan*1, M. Purushothaman2
1Alwar College of Pharmacy, Sun Rise University, Alwar, Rajasthan – 301030, India
2 Vasavi Institute of Pharmaceutical Sciences, Kadapa-516247, India

Most of the orally administered dosage forms have several physiology limitations such as GI transit time, incomplete drug adsorption due to incomplete release of drug from the device and too short residence time of the dosage forms in the adsorption region of GIT. To overcome these limitations many attempts have been made by scientist by designing various drug delivery systems among these systems, floating drug delivery system is one of the approaches which remain buoyant due to their lower density that of the GI and Intestinal fluids, both single and multiple unit systems have been developed.  Prolonged gastro retention of the therapeutic moiety may offer numerous advantages, including improvement of bio availability, therapeutic efficiency and possible reduction of dose. Floating drug delivery systems includes the various formulations like tablets, beads, microspheres etc., in this present review focusing the various types of formulations, formulation methods, polymers used, evaluation parameters and optimization methods used for developing the floating drug delivery systems

Keywords: Floating Drug Delivery System, Gastro retentive Drug Delivery System, Application.

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