Friday , 12 July 2024

Fabrication and evaluation of acyclovir Transdermal patches by using different polymer compositionps: In-Vitro

R. Venu Priya*1 and Vinesh Kumar2
1Research Scholar, Sun Rise University, Alwar, Rajasthan, India.

2Department of Pharmacy, Sun Rise University, Alwar, Rajasthan, India.

Transdermal drug delivery systems are becoming more popular in the field of modern pharmaceutics. Different matrix-type transdermal films containing acyclovir was formulated with an objective to study the effect of polymers on the release characters. Different blends of polymers such as ethyl cellulose (EC) and hydroxy propyl methyl cellulose (HPMC) were employed for the fabrication of films. The present study was carried out to develop matrix type transdermal patches containing acyclovir by solvent casting method. Span 80 is used as permeation enhancer and Propylene glycol 3% is used as plasticizer. The interaction among various components of the matrices was studied by performing Fourier transform infrared spectroscopic analysis. Formulated transdermal patches were evaluated with regard to physicochemical characteristics, in-vitro permeation studies and stability studies. All the prepared formulations showed good physical stability. The in-vitro permeation studies were performed using Franz diffusion cell. Out of all the formulated patches AF4 & AE3 showed good permeation in 24 hrs. So these two formulations were selected as best formulations.
Keywords: Acyclovir, Transdermal patches, Permeation enhancer, HPMC, ethyl cellulose.

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