Thursday , 11 July 2024

Evaluation of In Vitro Antidiabetic Activity of Ethanolic Root Extract of Cassia fistula L.

Veluru Manasa*, K. Sumanth, C. Madhavi Latha, Y. Prapurna Chandra
Department of Pharmacology, Ratnam Institute of Pharmacy, Pidathapolur (V&P), Muthukur (M), SPSR Nellore– 524 346

A b s t r a c t
This present study has been undertaken to evaluate the preliminary phytochemical analysis, in vitro anti-diabetic activity.  The root of the plant extract of Cassia fistula L. indicates the presence of secondary metabolites like flavonoids, glycosides were used. The presence of these phytochemicals in high concentration account for the significant hypoglycemic effect of Cassia fistula L. It is a tropical herb/frob which has been traditionally used in the management DM. In vitro alpha-amylase enzyme inhibition of Cassia fistula L. extract was evaluated. The study shows significant inhibition activity of ethanolic root extract of Cassia fistula L. by using in vitro -amylase and glucose diffusion assay, so further the compound isolation, purification and characterization which is responsible for inhibiting activity, has to be done for the usage of antidiabetic agent.

Keywords: Cassia fistula, anti-diabetic activity, DM (diabetes melllitus)

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