Evaluation of Hypoglycemic Potential Effect of Phyllanthus Niruri in Alloxan Induced Diabetic Male Swiss Albino Mice

Pabbathi Venkata Sravani*, C. Madhavi Latha, Y. Prapurna Chandra
Department of Pharmacology, Ratnam Institute of Pharmacy, Pidathapolur (V&P), Muthukur (M), SPSR Nellore District – 524 346

A b s t r a c t
The present study on diabetes was carried out on the male swiss albino mice. The project was aimed to study the antidiabetic activity of leaf extracts of phyllanthus niruri in Alloxan induced diabetes. Serum blood glucose levels were anazyled by using auto analyzer. Histopathological studies were carried out to confirm the biological changes. In the present study administration of Alloxan significant increase of blood glucose levels in Diseased, Standard, Ethanolic and Aqueous groups. Administration of seed extracts of phyllanthus niruri shown significant decrease in the ethanolic and Aqueous groups. Thus seed extracts of phyllanthus niruri shows hypoglycemic potential effect.
Keywords: phyllanthus niruri, antidiabetic activity, Alloxan, hypoglycemic, blood glucose, albino mice