Wednesday , 2 December 2020

Evaluation of Acetic Acid Induced Ulcer and Antioxidant Activities of Datura Stramonium Plant Phenolic Extracts

Askani Krishna Kumari1, D. Swamy Charan2, 3Gampa Vijay Kumar3
1,2,3 KGR Institute of Technology and Management, Rampally Vill, Kesara Mdl , Medchal Dist-501301, Telangana, India.

A B S T R A C T
In the present work an attempt has been made to evaluate the anti ulcer and anti oxidant activities by using herbal remedy Datura stramonium. Datura stramonium (Solanaceae) is a common weed found throughout India. The Datura stramonium which belongs to Datura genus of Solanaceae family may contain similar type of tropane alkaloids & may show similar parasympatholytic action. The medicinal use of parasympatholytic drugs like atropine shows anti-secretary, which may be useful in the treatment of peptic ulcer hence this work has been taken up. The phenolic extract of Datura stramonium treated groups shows a significant effect when compared to control group animals which indicating that the plant having the anti ulcer activity. The effective dose was found to be 200-mg/kg body weight by using fixed dose method (as per the OECD guideline 420). The acute toxicity study conducted for phenolic extract of Datura stramonium indicates that safe up to 2000mg/kg  body weight. Ulcer can minimize by some life style changes like, avoid eating at least two hours before bed time and whatever foods might cause discomfort, such as alcohol, caffeine beverages (coffee and pop), fatty foods, and highly seasoned foods. It is important to try to stop smoking, since smoking has been linked to ulcer formation, reduced healing, and ulcer recurrences. Also try to minimize stress in life.  Stress may worsen ulcer symptoms.
Keywords: Datura stramonium, Anti Ulcer, Phenolic extraction

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