Supriya Deogire*, Sonali Mahaparale Padm. Dr. D.Y. Patil College of Pharmacy Akurdi, Pune–44, India.
The present work is aimed at preparing and evaluating sustained release matrix tablets of Lamivudine using Synthetic polymer i.e. Glyceryl behenate (Compritol 888) with different polymers concentration by direct compression and Hot melt granulation techniques. Lamivudine is a potent hydrophilic anti viral agent indicated for treatment of AIDS (Acquired Immunodeficiency Syndrome). It was found that the cumulative percent drug release decreased with increasing concentration of Polymer. Matrix tablets were prepared by direct compression method and hot melt granulation technique taking Glyceryl behenate (Compritol 888) as different concentration in increasing order and F001 to F008 total eight formulation were prepared. The powders are evaluated for flow properties and tablets were evaluated for hardness, friability, dissolution rate, kinetics studies etc. No chemical interaction between Drug and the polymer were seen as confirmed by FT-IR studies. Among all the formulation made by direct compression and hot melt granulation it was found that the formulation containing Glyceryl behenate (Compritol 888) in higher concentration using Hot melt granulation showing best sustained release or retard the release of drug up to 24 hours.
Keywords: Lamivudine; Glyceryl behenate (Compritol 888); hot melt granulation; Sustained release.