Sanjay K. Sharma*, Deepak Sharma,Vaibhav Saxena, Manish Jaimini, Shailender Mohan Department of Pharmaceutics, Jaipur College of Pharmacy, ISI-15, RIICO, Sitapura, Jaipur (Raj) - 302022, India
An attempt was made to formulate the floating alginate beads containing Propranolol hydrochloride, using foam solution. Propranolol hydrochloride is a sympatholytic non-selective beta blocker with its absorption site at stomach. propranolol hydrochloride is more soluble in acidic pH and slightly soluble in neutral or alkaline pH conditions. Therefore development of a sustained release formulation of propranolol hydrochloride is advantageous, if the system can remain in stomach for prolonged period of time. Three polymers sodium alginate, poloxamer188, poloxamer407 were used for the present study. Poloxamer were used to impart buoyancy to the beads. Total 14 formulations were prepared with different polymer concentrations. Formulated beads were evaluated for production yield, particle size, swelling index, buoyancy, drug entrapment efficiency, morphology, in vitro release characteristics. Formulated beads showed satisfactory floating characteristics and subjected for in vitro release study using 0.1N HCl (pH 1.2) in USP apparatus II (paddle type). The results indicated that sodium alginate with poloxamer 188 sustain the drug release better up to 12 hr. To analyze the mechanism of drug release from the beads, the in vitro release data was fitted into various release models.
Keywords: Floating Beads, Propranolol hydrochloride, HPMC, Buoyancy Test, Poloxamer.