Thursday , 11 July 2024

Development and Evaluation of Fast Dissolving Tablets of Emapagliflozin by Enhancing Dissolution Rate and Bioavailability

K. Tejaswari*1, Dr. G.Gopi2, Dr. P. K. Prakash Reddy3
1Department of Pharmaceutics, Mahathicollege of Pharmacy, CTM Cross roads, Madanapalle.-517319.
2Professor and HOD, Department of Pharmaceutics, Mahathi College of Pharmacy, CTM Cross Roads, Madanapalle.-517319.
3Principal and Professor, Mahathi College of Pharmacy, CTM Cross Roads, Madanapalle.-517319.

A suitable analytical method based on UV-Visible spectrophotometry was developed to identify Empagliflozin, with a maximum absorbance (λmax) at 257 nm in 0.1N HCL. A direct compression method was established for the manufacture of mouth disintegrating tablets (MDTs) of Empagliflozin, employing super disintegrants such as Sodium Starch Glycolate (SSG), Crospovidone, and Croscarmellose Sodium. The prepared MDTs were evaluated for parameters including hardness, friability, weight variation, and drug content, all of which were found to be within permissible limits. An in vitro drug release study indicated that the F-6 formulation exhibited the best performance, achieving 99% drug release within 30 minutes. Notably, formulations containing Crospovidone demonstrated superior release profiles compared to others. This investigation successfully developed MDTs of Empagliflozin that release the drug within 30 minutes, meeting the objective of creating effective tablets with minimal excipients and a straightforward manufacturing process.

Keywords: Empagliflozin, Crospovidone, Sodium Starch Glycolate, mouth disintegrating tablets.

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