Thursday , 11 July 2024

Formulation and Evaluation of Microparticle Controlled Release Solid Dosage form of Remogliflozin

G. Manohar*1, Dr. G. Gopi2, Dr. P. K. Prakash Reddy3
1Department of Pharmaceutics, Mahathicollege of Pharmacy, CTM Cross roads, Madanapalle.-517319.

2Professor and HOD, Department of Pharmaceutics, Mahathi college of pharmacy, CTM Cross roads, Madanapalle.-517319.
3Principal and Professor, Mahathi College of Pharmacy, CTM Cross roads, Madanapalle.-517319.

This study investigates the influence of different concentrations of controlled-release (CR) polymers on the release profiles of tablets. It was observed that as the concentration of CR polymers increased, the order of CR also increased, with formulations F2 exhibiting superior CR compared to F1 (HPMC), F4 to F3 (GG), and F6 to F5 (SA). When natural CR polymers, sodium alginate (SA) and guar gum (GG), were used alone at concentrations of 30% and 45%, no CR effect was sustained up to 12 hours, indicating their ineffectiveness as sole CR agents. Among all the polymers tested, 45% HPMC (F2) demonstrated the most effective CR. Consequently, further studies explored the effect of combining natural CR polymers (SA and GG) with HPMC while maintaining a constant 45% HPMC concentration (formulations F7, F8, and F9). The results indicated that the formulation comprising 45% HPMC + 10%SA + 10%GG (F9) provided the best CR due to the synergistic release mechanisms of the three polymers. The order of CR efficacy was determined to be F9 > F7 > F8. The dissolution data clearly showed that the combination of HPMC with both natural polymers resulted in superior CR compared to formulations containing HPMC with a single natural polymer or HPMC alone. Thus, combining HPMC with natural polymers is a more effective strategy for achieving optimal controlled-release profiles in tablet formulations.

Keywords: Controlled-release, polymers, HPMC, Remogliflozin

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