Sunday , 9 May 2021

Antidiabetic Activity of a Polyherbal Preparation in Streptozotocin-Nicotinamide (STZ-NICO) Induced Diabetic Rats

Amit Agrawal1, Ameeta Argal2
1Research Scholar, Institute of Pharmaceutical Science & Research Center, Bhagwant University, Ajmer, Rajasthan, India-305004
2Professor, TIT College of Pharmacy, Bhopal, Madhya Pradesh, India-462042

A B S T R A C T
The present work was executed to evaluate the anti-diabetic potency of a polyherbal preparation. The objective of this study is to induce experimental diabetes mellitus using Alloxan in normal Albino wistar rats and study the anti­diabetic activity of polyherbal formulation by comparison of changes in body weight and levels of glucose between normal and diabetic rats. Hypoglycemic agents from natural and synthetic sources are available for treatment of diabetes. Indian medicinal plants have been found to be useful to successfully manage diabetes. The effect of alcoholic extract of poly herbal preparation containing leaves of Gymnema sylvestre, fruits of Momordica charantia, rhizomes of Curcuma longa, seeds of Eugenia jambolana and fruits of Embilica officinalis was investigated in normal, glucose load conditions and alloxan ­induced diabetic rats. Significant anti diabetic activity was exhibited by the poly herbal formulation. Serum cholesterol levels were found to be increased in diabetic animals. Treatment with the polyherbal Preparation 200 mg/kg body wt and 400 mg/kg body wt for 10 days in diabetic animals has shown significant decrease in serum glucose and biochemical parameters (urea, creatinine, triglycerides and cholesterol) levels in comparison to control animals.
Keywords: Gymnema sylvestre, Momordica charantia Curcuma longa, Eugenia jambolana, Embilica officinalis, Polyherbal Formulation.

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