Yadav Hanuman Singh1,Gadegone Sunita2 and Pande Hemant1
1Dr. Ira Nimdeokar Research Center for Chemistry, Hislop College, Nagpur 440001, India.
2Department of Chemistry, Kamla Nehru Mahavidyalaya, Nagpur 440009, India.
A B S T R A C T
One pot synthesis of acid esters by Stobbe condensation of alkylidene / arylidene succinates and aldehydes or ketones, their subsequent hydrolysis to diacids were reported. The Stobbe condensation of various aromatic aldehydes or ketones with dimethyl succinate gives different types of diacids [2a , (Z)-2-(diphenylmethylene) -3-(furan-2-yl-methylene) succinic acid)], [2b, 2- (diphenylmethylene)-3-methylene succinic acid], [2c, (Z)- 2 -(furan-2-yl-methylene)-3-methylene succinic acid))], [2d, (2-methylene)-3-(propan-2-ylidene) succinic acid)] through green approach. The improved yields of Fulgenic acid were observed by the green approach method as compared with other classical methods employed so far.
Keywords: Green synthesis, Stobbe condensation, aryl aldehydes & ketones and their products.