Sunday , 9 May 2021

One Pot Synthesis of Fulgenic Acids from Stobbe Condensation Method

Yadav Hanuman Singh1,Gadegone Sunita2 and Pande Hemant1
1Dr. Ira Nimdeokar Research Center for Chemistry, Hislop College, Nagpur 440001, India.
2Department of Chemistry, Kamla Nehru Mahavidyalaya, Nagpur 440009, India.

A B S T R A C T
One pot synthesis of acid esters by Stobbe condensation of alkylidene / arylidene succinates and aldehydes or ketones, their subsequent hydrolysis to diacids were reported. The Stobbe condensation of various aromatic aldehydes or ketones with dimethyl succinate gives different types of diacids [2a , (Z)-2-(diphenylmethylene) -3-(furan-2-yl-methylene) succinic acid)], [2b, 2- (diphenylmethylene)-3-methylene succinic acid], [2c, (Z)- 2 -(furan-2-yl-methylene)-3-methylene succinic acid))], [2d, (2-methylene)-3-(propan-2-ylidene) succinic acid)] through green approach. The improved yields of Fulgenic acid were observed by the green approach method as compared with other classical methods employed so far.
Keywords: Green synthesis, Stobbe condensation, aryl aldehydes & ketones and their products.   

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