Amit Parashar*, Poonam Sharma, Satish Goyal, Ashok Kumar
Department of Chemistry, Hardayal Technical Campus, Mathura, India
E-mail : [email protected]
Conjugated fatty acids (CFAs) are a mixture of positional and geometric isomers of polyunsatu-rated fatty acids with conjugated double bonds. Reports indicate that CFAs have potent beneficial effects, including antitumor, antiobese, antiatherogenic and antidiabetic activities. The molecules have also been shown to prevent the onset of hypertension. Recent reports suggest that each CFA isomer has different functions, for example the 10trans; 12cis isomer of conjugated linoleic acid (CLA) has anticarcinogenic, antiobese and antidiabetic effects, whereas the 9cis, 11trans-CLA isomer exerts an anticancer effect. Although it would be interesting to know the effects of CFAs on humans, there are only few reports concerning the anticancer and antiobese effects of CLA in humans. More detailed evaluations of the physiological bioactivities of CFA isomers on lifestyle related diseases in humans and animals will be of great interest in future studies.
Key words: conjugated fatty acids, cancer, obesity, hypertension, Life-style related deseases