Tuesday , 25 February 2020

Tag Archives: bioavailability

Design and Development of Pantoprazole Floating In-Situ Gel

Bhargavi Tambali*, Venkata Ramana Bachu, Venkata Badarinath Atluri Dr. K. V. Subba Reddy Institute of Pharmacy, Kurnool, Andhra Pradesh, India – 518218 A B S T R A C T The aim of this investigation is to formulate and evaluate floating in- situ gel of Pantaprazole solution by using polymer dispersion technique. Pantoprazole is a proton pump inhibitor (PPI) that ... Read More »

A Review on Solubility Enhancement Using Hydrotropy

Angilicam Avinash*, Avula Sushma, Koneti Lalasa, Siddabathina Prasanth Kumar, Thumati Gowthami, Dr. M. Sreenivasulu Narayana Pharmacy College, Chinthareddypalem, Nellore, Andhra Pradesh, India-524003. A B S T R A C T The effectiveness of formulation depends particularly on how efficiently is drug available at the site of action. Therapeutic effectiveness of a drug basically depends upon bioavailability and the solubility of drug ... Read More »

Formulation and Evaluation of Diclofenac Sodium Polymeric Buccoadhesive Film

J. Ravi Kumar Reddy*, P Neelaphar, Chakka Gopinath Department of Pharmaceutics, Annamacharya College of Pharmacy, Rajampeta–516126, Kadapa, Andhra Pradesh, India A B S T R A C T In this study the attempt was made for preparation of buccoadhesive films of Diclofenac sodium by using bioadhesive polymers like sodium alginate and PVP K-30 which will improve oral bioavailability by sparing ... Read More »

Bioequivalence Comparison between two Different Formulations of Alverine Citrate 120mg Capsules: An Open Label, Balanced, Randomized-Sequence, Single-Dose, Two-Period Crossover Study in Healthy Male Volunteers

I. Sarath Chandiran*1, Raghunadha Reddy Seelam2, Seelam Sai Satyanaraya Reddy3, Ravindra Reddy S3 1Professor, Ratnam Institute of Pharmacy, Pidathapolur, SPSR Nellore-524346, Andhra Pradesh, India 2Department of Pharmaceutical Science, School of Pharmacy, University of Maryland, Pine Street, Baltimore, Maryland 21201, USA. 3Vardhaman College of Engineering, Hyderabad, Telangana, India. A B S T R A C T This present bioequivalence study was designed ... Read More »

Bioequivalence and Pharmacokinetic Comparison between Extended Release Capsules of Carvedilol Phosphate 40mg: An Open Label, Balanced, Randomized-Sequence, Single-Dose, Two-Period Crossover Study in Healthy Male Volunteers

I. Sarath Chandiran1*, Raghunadha Reddy Seelam2, Seelam Sai Satyanaraya Reddy3, Ravindra Reddy S3 1Professor, Ratnam Institute of Pharmacy, Pidathapolur, SPSR Nellore-524346, Andhra Pradesh, India 2Department of Pharmaceutical Science, School of Pharmacy, University of Maryland, Pine Street, Baltimore, Maryland 21201, USA. 3Vardhaman College of Engineering, Hyderabad, Telangana, India. A B S T R A C T This present bioequivalence study was designed to ... Read More »

Solid Dispersion-A Strategy for Improving the Solubility of Lipophilic Drugs

Krishna Moorthy S.B,*1 Sandeep. J2, Rajalakshmi.R1, Rubiya SK1, Saddam hussain. SK1   1Department of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, A. Rangampet, Tirupathi, Andhra Pradesh, India. 517102. 2Department of Pharmaceutics, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupathi, Andhra Pradesh, India. 517503. Abstract Improving oral bioavailability of drugs those given as solid dosage forms remains a challenge for the formulation scientists due to solubility ... Read More »

A Review on Innovative Formulation Approach to Enhance Occular Bioavailability

Harendra Prasad*1 and Navneet Kumar Verma2 1Chhatrapati Shahuji Maharaj Group of Institution Faculty of B.Pharmacy, Allahabad U.P., India 2Rameshwaram Institute of Technology and Management Lucknow, U.P, India Received: 14 June 2014, Accepted: 19 July 2014, Published Online: 10 August 2014 Abstract Conventional eye drops shows relatively low bioavailability due to poor precorneal contact time. In situ hydrogel are of great ... Read More »

Solubility Enhancement Techniques and Use of Dendrimers in the Solubilization of Water Insoluble and Poorly Soluble Drugs-A Review

Navneet Kumar Verma*1, Anubha Gupta1, Harendra Prasad2, Asha Roshan3, Shobhit Prakash Srivastava4, Vikash Chandra4  1Department of Pharmacy, Rameshwaram Institute of Technology and Management, Lucknow, (U.P), India 2Faculty of B. Pharmacy, CSM Group of Institution, Allahabad, (U.P), India 3R.K. College of Pharmacy, Azamgarh, (U.P), India 4Dr. M.C. Saxena College of Pharmacy, Lucknow, (U.P), India Received: 6 May 2014, Accepted: 12 June ... Read More »

Preparation of Diltiazem Base from Official Salt form and its Characterization

ABOUT AUTHOR B. Venkateswara Reddy*, S. Satyanandam Department of Pharmaceutics, School of Pharmacy, Monad University, Hapur, U.P., India Abstract Diltiazem hydrochloride (DTZ), a drug used in the treatment of Cardiac arrhythmias and has recently become very popular for treatment of old age hypertension. The drug is well absorbed form gastrointestinal tract, but its bioavailability is low due to extensive first ... Read More »

Method used for Solubility Enhancement of Poorly water Soluble Drug-A Review

About author Prasad Harendra*, Verma Navneet Kumar Rameshwaram Institute of technology and Management Lucknow, U.P. India E-mail: navneet_its04@rediffmail.com Abstract The slow dissolution rate exhibited by poorly water-soluble drugs is a major challenge in the drug development process. Following oral administration, drugs with slow dissolution rates generally show erratic and incomplete absorption which may lead to therapeutic failure. The aim of ... Read More »

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