Design and Development of Pantoprazole Floating In-Situ Gel

Bhargavi Tambali*, Venkata Ramana Bachu, Venkata Badarinath Atluri
Dr. K. V. Subba Reddy Institute of Pharmacy, Kurnool, Andhra Pradesh, India – 518218

A B S T R A C T
The aim of this investigation is to formulate and evaluate floating in- situ gel of Pantaprazole solution by using polymer dispersion technique. Pantoprazole is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production by covalently binding to the (H+, K+)-ATPase enzyme system at the secretory surface of the gastric parietal cell. This effect leads to inhibition of both basal and stimulated gastric acid secretion, irrespective of the stimulus. The binding to the (H+, K+)-ATPase results in a duration of anti secretory effect that persists longer hours for all doses tested (20 mg to 120 mg). The metabolism of pantoprazole is independent of the route of administration, with a half-life of approximately 1.1 hours. However in patients with a mutation in the gene encoding the CYP2C19 enzyme, the half-life may be up to 3 hours. Pantoprazole is selected as a model drug for this investigation because its oral dose is 20-120 mg varied , short biological half life (1-3 hrs) and extensive first pass metabolism. 40 mg for sustained release tablets effect lasts for usually 6-8 hrs according to the survey. To improve the oral bioavailability, reduce the frequency of administration pantoprazole was designed as solution converts into gel in the presence of gastric solution (pH 1-2), which was designed by using sodium alginate as sustaining polymer, calcium carbonate as cross linking agent and floating behavior by the help of calcium carbonate and citric acid by dispersion technique and subjected to in vitro evaluation studies
Keywords: Pantoprazole, proton pump inhibitor, Bioavailability, evaluation