Vinay Kumar Perala1, Arun kumar revelly1, Sai kumar koochana1, Rajasekar Reddy Poonuru*2
1St. Peters College of Pharmacy, Madikonda, Kazipet, Warangal-506142, Telangana, India.
2St. Peters Institute of Pharmaceutical sciences, Hanamkonda, Telangana, India -506001.
A B S T R A C T
The current research was to improve the solubility of the poorly soluble drug iloperidone by preparing coprecipitates. Coprecipitation is defined as the simultaneous precipitation of a normally main aim soluble component with a macro-component from the same solution by the formation of mixed crystals, by adsorption, occlusion or mechanical entrapment.The aqueous solubility of the drug was found to be (0.00304mcg/ml). Different coprecipitates were prepared by using different concentrations of Captisol. The coprecipitates were prepared by liquid antisolvent technique. The prepared coprecipitates were characterized for their solubility and in vitro drug release studies. In vitro dissolution performance was evaluated using 6.8 pH phosphate buffer as dissolution media and the samples were analyzed using UV-visible spectrophotometer. It was observed from in vitro drug release studies that there was a significant improvement in solubility and dissolution of iloperidone from coprecipitates when compared to tablet and pure drug. Thus it can be concluded that the enhancement of solubility and dissolution of iloperidone can be achieved by preparing coprecipitates.
Keywords: Coprecipitation, Antisolvent technique, Solubility enhancement techniques