Veeralakshmi V*1, Ramu Ramprasad2, Jeyaraman Amutha Iswarya Devi1 and
1Department of Pharmaceutical Chemistry, Arulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnan Koil-626126.
2Department of Pharmaceutics, Arulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnan Koil-626126.
A B S T R A C T
The efforts to find alternative antimalarial medicine have not essentially solved the problem of malaria control because of the presence of medication resistance. The Plasmodium resistance to antimalarial medicine is resulted from malaria treatment failure. Therefore, the availability of new antimalarial medicine is urgently needed to overcome the resistance problems. Taxonomical evaluations of Begonia trichocarpa Dalz. was carried out by the observation of habit, description of plant, nature and type of leaf, study of flowers including character of the androecium and gynoecium, nature stem, type of roots and fruits. Coarse powder of Begonia trichocarpa Dalz. was extracted using ethanol 96% by maceration method. An in vitro anti-plasmodial activity test was carried out by using Candle Jar method. The doses of administration of ethanolic extract of Begonia trichocarpa Dalz were at 1000; 500; 250; 100 and 50 µg/mL concentration. The results of the study included parasitemia percentage, P. falciparum growth inhibition percentage and IC50 value. The IC50 value of the ethanol extract of Begonia trichocarpa Dalz. was 2.46 µg/mL. The in vitro antiplasmodial activities of ethanol extracts of Begonia trichocarpa Dalz. were categorized to be very active.
Keyword: Antimalarial, Antiplasmodial, Begonia trichocarpa Dalz., P. falciparum.