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Gowramma A*1, A. Mounika2, A. Vinod babu2, P. Ratna kala2, B. Prathibha2, E. Susanna2, P. Siva kumari
1Asst. professor, Department of Pharmaceutics, Jagan’s College of Pharmacy, Jangala kandriga, SPSR Nellore, A.P, India.
2Jagan’s College of Pharmacy, Jangala kandriga, SPSR Nellore, A.P, India
A B S T R A C T
The valsartan microballoons were prepared by using PVPk30 as a stabilizer & HPMC is a carrier with specific ratio of solvents (Acetone & water). The results were obtained from in vitro dissolution data revealed that the prepared valsartan microballoons (F2) were having good buoyancy and entrapment efficiency. It was further concluded that with the variation in concentration of polymer, microballoons of different size, % practical yield and drug content can be obtained with satisfactory results. Microballoons were prepared by using solvent evaporation method, F2 is optimized formulation & it showed highest percentage drug release. SEM results were also showed compared to pure drug the F2 consists of round shaped less particle size (25µm). So, it can be concluded that microballoon drug delivery system can be used as gastro retentive drug delivery system and the mentioned technique is a promising tool for effective microballoons formation.
Keywords: Microballoons, valsartan, solvent evaporation method, gastro retention
