Wednesday , 18 July 2018

Formulation and Evaluation of Chitosan Gels Enriched with Tropicamide Loaded Solid Lipid Nanoparticles for Ocular Drug Delivery

Yerikala Ramesh*1, Jayachandra Reddy Peddappi Reddigari 2, Chandrasekhar B. kothapalli3
1Research Scholar, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu, Andhra Pradesh, India
2Principal & Professor, Department of Pharmaceutical Analysis, Krishna Teja Pharmacy College, Chadalawada Nagar, Renigunta Road, Tirupathi – 517506, Andhra Pradesh, India.
3Director & Professor, Department of Pharmaceutical Chemistry, JNTUA – Oil Technological Pharmaceutical Research Institute, Ananthapuramu – 515001, Andhra Pradesh, India.

ABSTRACT
The aim of present work Formulation & Evaluation of chitosan gels enriched with tropicamide loaded solid lipid nanoparticles for ocular drug delivery. The preparation of tropicamide loaded solid lipid nanoparticles by cold homogenization method. The interaction between drug, lipids & polymer by performing with FTIR there is no incompatibility. The morphological particles were carried out by TEM in solid lipid nanoparticle formulation. The average particle size was ranges from 212.7 ± 10.27 nm to 530.3±6.14nm. The zeta potential ranges from -0.26 ± 1.2 mV to 6.16 ± 0.9 mV. The entrapment efficiency of solid lipid nanoparticles contains free tropicamide were ranges from 78.16 % to 94.37 %. The polydispersity index of Tropicamide loaded solid lipid nanoparticles was ranges from 0.612 ± 0.12 to 0.916 ±0.24. The drug content of Tropicamide loaded solid lipid nanoparticles was ranges from 0.121mg/ml to 0.916 mg/ml. The prepared chitosan gels enriched in solid lipid nanoparticles, the pH of the formulations was in the range of 6.4 to 6.8. The gelling strength was ranges from 65 ± 1 sec to 124 ± 2 sec. The Bio adhesive force was ranges from 10.15 ±1.20 dynes/cm2 to 18.19 ± 1.31 dynes/cm2. The viscosity studies were ranges 412 ± 1.25 cps to 623 ± 1.48 cps.. Among the sixteen formulation In vitro diffusion studies of TSLNGF10 shows the 98%, it follows the zero order kinetics. The ocular irritancy studies among all the formulation it indicates the TSLNGF10 was shows the non-irritant with excellent ocular tolerance, does not find out redness, there is no swelling towards watering of the eye, it may shows the excellent mydriatic activity.

Keywords: Solid Lipid Nanoparticles, Gels, Chitosan, in vitro diffusion studies, Ocular drug delivery.

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