Ch. Srilatha*1, P. Prvallika Reddy1, Dr. M. Ravi Kumar1, Dr. K. Someshwar2
1Geetanjali College of Pharmacy, Keesara, Rangareddy, Telangana, India
2Manager, Formulation R&D, Karthikeya Drugs and Pharmaceuticals Private Limited, Kothapet, Hyderabad.
A B S T R A C T
In the present work, bioadhesive microspheres of Valacyclovir using Sodium alginate along with Carbopol 934, Carbopol 971, HPMC K4M as copolymers were formulated to deliver Valacyclovir via oral route. The results of this investigation indicate that ionic cross linking technique Ionotropic gelation method can be successfully employed to fabricate Valacyclovir microspheres. The technique provides characteristic advantage over conventional microsphere method, which involves an “all-aqueous” system, avoids residual solvents in microspheres. Other methods utilize larger volume of organic solvents, which are costly and hazardous because of the possible explosion, air pollution, toxicity and difficult to remove traces of organic solvent completely. FT-IR spectra of the physical mixture revealed that the drug is compatible with the polymers and copolymers used. Micromeritic studies revealed that the mean particle size of the prepared microspheres was in the size range of 512-903µm and are suitable for bioadhesive microspheres for oral administration. Increase in the polymer conc. led to increase in %Yield, % drug entrapment efficiency, Particle size, % swelling and % Mucoadhesion. The in-vitro drug release decreased with increase in the polymer, copolymer conc. Based on the results of evaluation tests formulation coded T4 was concluded as best formulation. The optimized Formulation microspheres were packed in hard gelatin capsule shells.
Keywords: Valacyclovir, Microspheres, Carbopol Polymers