Thursday , 23 March 2017

Formulation and In-Vitro Evaluation of Doxorubicin Microspheres for the Treatment of Lymphoblastic Leukemia

Kondru Lalitha*, Beedha Saraswathi
Mother Teresa Pharmacy College, Kothuru, Sathupally- 507303, Khammam, Telangana, India

In the present work, bioadhesive microspheres of Doxorubicin using Sodium alginate along with Carbopol 934, Carbopol 971, HPMC  K4M as copolymers were formulated to deliver Doxorubicin via oral route. The results of this investigation indicate that ionic cross linking technique Ionotropic gelation method can be successfully employed to fabricate Doxorubicin microspheres. The technique provides characteristic advantage over conventional microsphere method, which involves an “all-aqueous” system, avoids residual solvents in microspheres. Other methods utilize larger volume of organic solvents, which are costly and hazardous because of the possible explosion, air pollution, toxicity and difficult to remove traces of organic solvent completely. Micromeritic studies revealed that the mean particle size of the prepared microspheres was in the size range of 512-903µm and are suitable for bioadhesive microspheres for oral administration.Increase in the polymer concentration led to increase in % Yield, % Drug entrapment efficiency, Particle size, % swelling and % Mucoadhesion. The in-vitro mucoadhesive study demonstrated that microspheres of Doxorubicin using sodium alginate along with Carbopol934 as copolymer adhered to the mucus to a greater extent than the microspheres of Doxorubicin  using sodium alginate along with Carbopol 971 and HPMC K4M as copolymers. The  invitro drug release decreased with increase in the polymer and copolymer conc. Based on the results of evaluation tests formulation coded T4 was concluded as best formulation.
Keywords: Doxorubicin,Carbopol, Microspheres

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