Thursday , 23 May 2024

Preparation and Evaluation of Mucoadhesive Opthalmic Niosomes of Acyclovir Using Chitosan and Carbopol

Dr. Raghvendra1*, Pragya Sharma1, Nidhi Dhama2
1Assistant Professor, Department of Pharmaceutics, Aligarh College of Pharmacy, Aligarh, U.P., India, 202001
2Assistant Professor, Department  of Pharmaceutics, Translam Institute of Pharmaceutical Education and Research, Meerut, U.P. India, 250001

Niosomes have been reported as a possible approach to deliver the drug to ophthalmic cavity. Niosomes were formed using Span (20, 40, 60, and 80) and cholesterol in different molar ratio using Acyclovir as the model drug; Niosomes were formed using Reverse phase evaporation method. The formed vesicles were characterized for entrapment efficiency, particle size, Zeta potential, Stability etc. results of the study showed that Niosomes formed with Span60 and cholesterol containing 90% span 60 and 10% cholesterol gave maximum entrapment efficiency. The optimized Niosomes were further dispersed in polymeric solution of Chitosan and Carbopol separately, in-vitro release pattern suggested that a sustained release can be obtained, with better sustained release in Niosomes dispersed in polymeric solution of Chitosan. Results of studies suggest that Niosomes dispersed in polymeric solution of Chitosan can be used as promising vesicles for sustained delivery of drug to ophthalmic cavity.
Keywords: Acyclovir, Chitosan, Carbopol, Niosomes

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