Nimish.S*1, Dr. S.N. Sri Harsha2, K.S.S.N. Neelima2, D. Yashwanth Kumar2
1Dr. K.N. Modi University, Jaipur, Rajasthan, India
2SARC (Scientific and Applied Research Center), Hyderabad, India
A B S T R A C T
Microspheres of Zolpidem tartrate were prepared using the non-aqueous emulsification solvent evaporation method. The impacts of different factors such as stirring rate, concentration of acrycoat S 100 as matrix polymer on the characteristics of the microspheres were investigated. The morphology of microspheres was studied using optical and scanning electron microscopy and it was shown that microspheres had a spherical shape and smooth surface. The particle size of microspheres analyzed by optical microscopic method was affected by stirring rate and concentrations of acrycoat S 100. As the stirring rate increased the particle size decreases and as concentration of acrycoat increase the particle size also increase. Larger microspheres showed greater drug loading and smaller microspheres showed a faster drug release.
Keywords: Zolpidem tartrate, Acrycoat S 100, Microspheres, Non-aqueous solvent evaporation.