Friday , 26 May 2017

Evaluation of Ulcer protective effect of Ethanolic Extract of Canavalia gladiata in Wistar Rats

Hemant V.Deore*, Vinod S. Ahire, Swapnil B. Deshmukh, Harshal S. Bhandari, Dipak K. Borole
DCS’S A.R.A College of Pharmacy, Nagaon, Dhule, Maharashtra-424005

A B S T R A C T
Peptic ulcer is an important and prevailing problem in many developing countries. Many drugs are available for the treatment of peptic ulcer. But on chronic administration of these drugs causes various adverse effects. Therefore, herbal medicines seems to be an alternative due to their fewer adverse effects. Canavalia gladiata commonly called as sword bean belongs to the family fabaceae. Since it has got lot of significance in traditional medicine, the main aim of the present study is to evaluate the anti-ulcer activity of Canavalia gladiata in wistar rats. Based on acute oral toxicity study according to the OECD guideline, one dose i.e. 250 mg/kg was selected for study. In aspirin induced ulcer model, ulcer index and percentage inhibition were determined. Ranitidine at 20 mg/kg was used as the standard drug. Pretreatment of ethanolic extract of Canavalia gladiate pods showed significant (P<0.001) decrease in number of ulcers ulcer score index and increase in the percentage protection in aspirin- induced ulceration models. The ethanolic extract of Canavalia gladiate pods possesses significant antiulcer properties. In conclusion the antiulcer properties of the extract may be attributed to the presence of alkaloids and phenolic compounds present in the plant extract with various biological activities.
Keywords: Canavalia gladiate, Wistar Rats, Ulcer protective, fabaceae

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