Tuesday , 5 March 2024

Evaluation of Hepatoprotective activity of aqueous extract of Polycarpea corymbosa on D-Galactosamine-induced hepatotoxicity in rats

Shavika*, Preethi C
Department of Pharmacology, Teegala Krishna Reddy College of Pharmacy, Meerpet, Saroornagar, Hyderbad-500 097

Hepatoprotective activity of polycarpea corbosa Linn. Whole plant aqueous Extract-Shade dried and coarsely powdered plant (1 kg) was extracted successively with decocted in purified boiling water in the ratio of 1:9. Polyherbal formulation (Liv-52,500mg/kg) and Silmarin (25 mg/kg), were evaluated for hepatoprotective activity using D-Galactosamine (D-GalN) induced hepatotoxicity in rats. The parameters assessed were serum levels of Serum Glutamic Oxaloacetate Trasaminase (SGOT), Serum Glutamic Pyruvate (SGPT), Trasaminase (SGOT), Alkaline Phosphatase (ALP), total protein, albumin, globulin, total cholesterol, total bilirubin and blood sugar changes in liver. Test drug also shown to suppress MDA and improved the antioxidant enzymes (superoxide dismutase, catalase, Glutathione peroxidise) and GSH levels. The treatmant with aqueous extract (500mg/kg),has shown to significantly reversed the biochemical changes induced by D-Galactosamine in rats, which is comparable to standard herbal formalution, Liv-52  and silymarin at the employed doses, which evidencing the promising potential of aquoes extract of polycarpea corbosa Linn for hepatoprotective activity.

Keywords: Polycarpea carbosa Linn. Polyherbal formulation Liv-52, Hepatoprotective activity, D-Galactosamine (D-GalN)-induced hepatic damage.

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