Friday , 14 December 2018

Dissolution Enhancement of Racecadotril by using In-situ Micronization Technique

S. Sai Vikas*, M. Nirosha, T. Pragna, D. Shakeer, L. Chandana, D. Tarun
Department of Pharmaceutics, JNTUA-Oil Technological & Pharmaceutical Research Institute, Ananthapuramu, A.P, India.

A B S T R A C T
The main objective of In-situ Micronisation is to enhance the rate of dissolution and absorption of poorly water soluble drugs. Racecadotril is an anti-diarrheal drug that acts by inhibiting the enzyme enkephalinase and shows anti-secretary effect. It reduces the secretion of water and electrolytes into the intestine. Racecadotril is a BCS class-II drug that has poor water solubility. The intention of the present work is to improve the solubility of drug by the formation of microcrystals. Five formulations of Racecadotril containing varying concentrations of polymer (PVPK30) were designed. The microcrystals were prepared by solvent change method and were evaluated for Percentage crystal yield, Mean particle size, Percentage Drug content, In vitro dissolution studies and also they can be characterized by FT-IR, DSC, XRD & SEM. The In-vitro dissolution studies revealed that out of five formulations, formulation F5 was found to be optimized which showed less particle size & the drug release was found 98.89% at 60min.
Keywords: In-situ Micronization, Racecadotril, Microcrystals, PVPK30, Solvent change method.

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